Triphase Interface Synthesis of Plasmonic Gold Bellflowers as Near-Infrared Light Mediated Acoustic and Thermal Theranostics

被引：187
作者：
Huang, Peng [1 ]
Rong, Pengfei [1 ,2 ,4 ]
Lin, Jing [1 ]
Li, Wanwan [1 ]
Yan, Xuefeng [1 ]
Zhang, Molly Gu [1 ]
Nie, Liming [1 ,3 ]
Niu, Gang [1 ]
Lu, Jie [1 ]
Wang, Wei
Chen, Xiaoyuan [1 ]
机构：
[1] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
[2] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China
[3] Xiamen Univ, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Sch Publ Hlth, Xiamen 361005, Peoples R China
[4] Cent S Univ, Xiangya Hosp 3, Dept Radiol, Changsha 410013, Hunan, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 23期
基金：
美国国家科学基金会;
关键词：
EARTH FLUORIDE NANOCRYSTALS; PHOTOTHERMAL THERAPY; MULTIFUNCTIONAL NANOPARTICLES; GRAPHENE OXIDE; ULTRASOUND; NANOCAGES; NANORODS; DELIVERY; AGENT; SIZE;
D O I：
10.1021/ja503115n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We present a novel gold bellflower (GBF) platform with multiple-branched petals, prepared by a liquid-liquid-gas triphase interface system, for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Upon near-infrared (NIR) laser irradiation, the GBFs, with strong NIR absorption, showed very strong PA response and an ultrahigh photothermal conversion efficiency (eta, similar to 74% among the reported photothermal conversion agents. The excellent performance in PAI and PTT is mainly attributed to the unique features of the GBFs: (i) multiple-branched petals with an enhanced local electromagnetic field, (ii) long narrow gaps between adjacent petals that induce a strong plasmonic coupling effect, and (iii) a bell-shaped effectively amplify the acoustic signals during the acoustic propagation. Besides the notable PTT and an excellent PAI effect, the NIR-absorbing GBFs may also find applications in NIR light-triggered drug delivery, catalysis, surface enhanced Raman scattering, stealth, antireflection, IR sensors, telecommunications, and the like.
引用
收藏
页码：8307 / 8313
页数：7
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