Hemophagocytic Lymphohistiocytosis Associated With Parechovirus 3 Infection

被引：9

作者：

Aviner, Shraga ^{[1
,2
]}

Sofer, Danit ^{[3
]}

Shulman, Lester M. ^{[3
,4
]}

Bibi, Haim ^{[1
,2
]}

Weitzman, Sheila ^{[5
,6
]}

机构：

[1] Barzilai Govt Hosp, Dept Pediat, IL-78278 Ashqelon, Israel

[2] Ben Gurion Univ Negev, Fac Hlth Sci, Ashqelon, Israel

[3] Chaim Sheba Med Ctr, Israel Minist Hlth, Cent Virol Lab, Publ Hlth Serv, IL-52621 Tel Hashomer, Israel

[4] Tel Aviv Univ, Sackler Fac Med, Sch Publ Hlth, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel

[5] Hosp Sick Children, Div Pediat Hematol Oncol, Toronto, ON M5G 1X8, Canada

[6] Univ Toronto, Toronto, ON, Canada

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2014年 / 36卷 / 04期

关键词：

hemophagocytic lymphohistiocytosis; human parechovirus; meningitis; neonate; ADULT-ONSET; MUTATIONS; PRF1;

D O I：

10.1097/MPH.0000000000000015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hemophagocytic lymphohistiocytosis (HLH) denotes the common final pathway of a potentially fatal hyperinflammatory condition of diverse etiologies. We describe the first case of documented HLH associated with human parechovirus 3. A monoallelic Ala91Val mutation was found in the PRF1 gene, but the contribution of this mutation to HLH remains controversial. The diagnosis, based on accepted criteria, was established early in the course of the disease and led to successful treatment and complete recovery. The awareness of this new association is clinically important in facilitating early treatment, preventing organ damage, and increasing the likelihood of complete recovery.

引用

页码：E251 / E253

页数：3

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