High-Dose Vaginal Maintenance Metronidazole for Recurrent Bacterial Vaginosis: A Pilot Study

被引：22

作者：

Aguin, Tina ^{[1
]}

Akins, Robert A. ^{[2
]}

Sobel, Jack D. ^{[3
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI USA

[3] Wayne State Univ, Sch Med, Dept Infect Dis, Detroit, MI USA

来源：

SEXUALLY TRANSMITTED DISEASES | 2014年 / 41卷 / 05期

关键词：

ORAL METRONIDAZOLE; THERAPY; CLINDAMYCIN;

D O I：

10.1097/OLQ.0000000000000123

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The purpose of this study was to explore the benefit of high-dose intravaginal metronidazole as a maintenance therapy in reducing recurrence rates of bacterial vaginosis (BV). Eighteen women with a history of recurrent BV and symptomatic BV were treated with metronidazole 750 mg suppository intravaginally daily for 7 days. Those in remission by Amsel criteria received metronidazole 750 mg twice weekly for 3 months with further follow-up for 3 months. High-dose metronidazole intravaginally was associated with rare clinical recurrence during the period of use. After cessation of suppression therapy, recurrence was high.

引用

页码：290 / 291

页数：2

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