Efficacy of PD-1 blockade in tumors with MMR deficiency

被引：44

作者：

Lee, Valerie ^{[1
]}

Le, Dung T. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA

来源：

IMMUNOTHERAPY | 2016年 / 8卷 / 01期

关键词：

immune checkpoint inhibition; microsatellite instability; mismatch repair deficiency; MICROSATELLITE INSTABILITY; COLORECTAL-CANCER;

D O I：

10.2217/imt.15.97

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：1 / 3

页数：3

共 8 条

[1]

Boland CR, 2010, GASTROENTEROLOGY, V138, P2073, DOI [10.1053/j.gastro.2010.04.024, 10.1053/j.gastro.2009.12.064]

[2] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

[3] PD-1 Blockade in Tumors with Mismatch-Repair Deficiency [J].

Le, D. T. ;

Uram, J. N. ;

Wang, H. ;

Bartlett, B. R. ;

Kemberling, H. ;

Eyring, A. D. ;

Skora, A. D. ;

Luber, B. S. ;

Azad, N. S. ;

Laheru, D. ;

Biedrzycki, B. ;

Donehower, R. C. ;

Zaheer, A. ;

Fisher, G. A. ;

Crocenzi, T. S. ;

Lee, J. J. ;

Duffy, S. M. ;

Goldberg, R. M. ;

de la Chapelle, A. ;

Koshiji, M. ;

Bhaijee, F. ;

Huebner, T. ;

Hruban, R. H. ;

Wood, L. D. ;

Cuka, N. ;

Pardoll, D. M. ;

Papadopoulos, N. ;

Kinzler, K. W. ;

Zhou, S. ;

Cornish, T. C. ;

Taube, J. M. ;

Anders, R. A. ;

Eshleman, J. R. ;

Vogelstein, B. ;

Diaz, L. A., Jr. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (26) :2509-2520

[4] Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma [J].

Lyford-Pike, Sofia ;

Peng, Shiwen ;

Young, Geoffrey D. ;

Taube, Janis M. ;

Westra, William H. ;

Akpeng, Belinda ;

Bruno, Tullia C. ;

Richmon, Jeremy D. ;

Wang, Hao ;

Bishop, Justin A. ;

Chen, Lieping ;

Drake, Charles G. ;

Topalian, Suzanne L. ;

Pardoll, Drew M. ;

Pai, Sara I. .

CANCER RESEARCH, 2013, 73 (06) :1733-1741

[5]

Muro K, 2015, 2015 GASTR CANC S CA

[6]

NCCN National Comprehensive Cancer Network, 2015, GEN FAM HIGH RISK AS

[7] MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer [J].

Powles, Thomas ;

Eder, Joseph Paul ;

Fine, Gregg D. ;

Braiteh, Fadi S. ;

Loriot, Yohann ;

Cruz, Cristina ;

Bellmunt, Joaquim ;

Burris, Howard A. ;

Petrylak, Daniel P. ;

Teng, Siew-Leng ;

Shen, Xiaodong ;

Boyd, Zachary ;

Hegde, Priti S. ;

Chen, Daniel S. ;

Vogelzang, Nicholas J. .

NATURE, 2014, 515 (7528) :558-+

[8] Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability [J].

Umar, A ;

Boland, CR ;

Terdiman, JP ;

Syngal, S ;

de la Chapelle, A ;

Rüschoff, J ;

Fishel, R ;

Lindor, NM ;

Burgart, LJ ;

Hamelin, R ;

Hamilton, SR ;

Hiatt, RA ;

Jass, J ;

Lindblom, A ;

Lynch, HT ;

Peltomaki, P ;

Ramsey, SD ;

Rodriguez-Bigas, MA ;

Vasen, HFA ;

Hawk, ET ;

Barrett, JC ;

Freedman, AN ;

Srivastava, S .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (04) :261-268

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