Neuroinflammation associated with ultrasound-mediated permeabilization of the blood-brain barrier

被引：35

作者：

Jung, Olive ^{[1
,2
]}

Thomas, Alec ^{[1
]}

Burks, Scott R. ^{[3
]}

Dustin, Michael L. ^{[4
]}

Frank, Joseph A. ^{[3
,5
]}

Ferrer, Marc ^{[2
]}

Stride, Eleanor ^{[1
]}

机构：

[1] Univ Oxford, Inst Biomed Engn, Biomed Ultrason Biotherapy Biopharmaceut Lab, Oxford, England

[2] NIH, Natl Ctr Adv Translat Sci, Dept Preclin Innovat, Tissue Bioprinting Lab 3D, Bethesda, MD USA

[3] NIH, Clin Ctr, Frank Lab, Radiol & Imaging Sci, Bethesda, MD USA

[4] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthoped Rheumatol & Musculoskeletal, Oxford, England

[5] NIH, Natl Inst Biomed Imaging & Bioengn, Intramural Res Program, Bethesda, MD USA

来源：

TRENDS IN NEUROSCIENCES | 2022年 / 45卷 / 06期

关键词：

ACUTE INFLAMMATORY RESPONSE; FOCUSED ULTRASOUND; ALZHEIMERS-DISEASE; CONTRAST AGENT; SYSTEM; MICROBUBBLES; DISRUPTION; CAVITATION; DELIVERY; MRI;

D O I：

10.1016/j.tins.2022.03.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier (BBB) continues to represent one of the most significant challenges for successful drug-based treatments of neurological disease. Mechanical modulation of the BBB using focused ultrasound (FUS) and microbubbles (MBs) has shown considerable promise in enhancing the delivery of therapeutics to the brain, but questions remain regarding possible long-term effects of such forced disruption. This review examines the evidence for inflammation associated with ultrasound-induced BBB disruption and potential strategies for managing such inflammatory effects to improve both the efficacy and safety of therapeutic ultrasound in neurological applications.

引用

页码：459 / 470

页数：12

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