Highly enantioselective Reformatsky reaction of ketones: Chelation-assisted enantioface discrimination

被引：36

作者：

Ojida, A

Yamano, T

Taya, N

Tasaka, A

机构：

[1] Kyushu Univ, Grad Sch Engn, Dept Chem & Biochem, Higashi Ku, Fukuoka 8128581, Japan

[2] Takeda Chem Ind Ltd, Med Chem Res Labs, Osaka 5328686, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 18期

关键词：

D O I：

10.1021/ol0263189

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Highly enantioselective Reformatsky reaction of ketones was accomplished using cinchona alkaloids as chiral ligands. Chelation with the sp(2)-nitrogen adjacent to the reactive carbonyl center contributed the enantioface discrimination for the high enantioselectivities.

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页码：3051 / 3054

页数：4

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