Observations on the use of Bruton's tyrosine kinase inhibitors in SAR-CoV-2 and cancer

被引：8

作者：

Benner, Brooke ^{[1
]}

Carson, William E. ^{[2
]}

机构：

[1] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA

[2] Ohio State Univ, Div Surg Oncol, Dept Surg, N924 Doan Hall,410 W 10th Ave, Columbus, OH 43210 USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2021年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Bruton's tyrosine kinase; Sars-CoV-2; COVID-19; Cancer; Ibrutinib; Acalabrutinib; IL-1; beta; CELLS;

D O I：

10.1186/s13045-020-00999-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bruton's tyrosine kinase (BTK) inhibitors, drugs utilized in cancer, are being repurposed for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (COVID-19). Recently, BTK inhibitors acalabrutinib and ibrutinib have been found to protect against pulmonary injury in a small group of patients infected with SARS-CoV-2. The high levels of pro-inflammatory cytokines found in the circulation of COVID-19 patients with severe lung disease suggest the involvement of the innate immune system in this process. Understanding the potential mechanism of action of BTK inhibition in SARS-CoV-2 is clearly of importance to determine how acalabrutinib, ibrutinib and possibly other BTK inhibitors may provide protection against lung injury.

引用

页数：3

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