Scalable Methods for Device Patterning as an Outstanding Challenge in Translating Paper-Based Microfluidics from the Academic Benchtop to the Point-of-Care

Paper-based microfluidic devices offer unparalleled adaptability for the development of low-cost, point-of-care analytical tests. The potential for these devices to drastically improve access to healthcare around the globe is obvious, but very few tests have found success in clinical environments. Here, we identify manufacturing-specifically, methods to pattern paper devices at large scales-as a major barrier to translating prototype paper-based devices from the academic benchtop to the field. We introduce current methods used to pattern papers and discuss their utility as means to prototype and manufacture paper-based devices.