MicroRNA-432 contributes to dopamine cocktail and retinoic acid induced differentiation of human neuroblastoma cells by targeting NESTIN and RCOR1 genes

被引：40

作者：

Das, Eashita ^{[1
]}

Bhattacharyya, Nitai Pada ^{[1
]}

机构：

[1] Saha Inst Nucl Phys, Crystallog & Mol Biol Div, Kolkata 700064, India

来源：

FEBS LETTERS | 2014年 / 588卷 / 09期

关键词：

MicroRNA-432; NESTIN; RCOR1; MECP2; Neurite outgrowth; SH-SY5Y cells; TYROSINE-HYDROXYLASE; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; CHOLINERGIC DIFFERENTIATION; NEURAL DIFFERENTIATION; SYMPATHETIC NEURONS; NEURITE OUTGROWTH; NERVOUS-SYSTEM; MESSENGER-RNA; EXPRESSION;

D O I：

10.1016/j.febslet.2014.03.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNA (miRNA) regulates expression of protein coding genes and has been implicated in diverse cellular processes including neuronal differentiation, cell growth and death. To identify the role of miRNA in neuronal differentiation, SH-SY5Y and IMR-32 cells were treated with dopamine cocktail and retinoic acid to induce differentiation. Detection of miRNAs in differentiated cells revealed that expression of many miRNAs was altered significantly. Among the altered miRNAs, human brain expressed miR-432 induced neurite projections, arrested cells in G0-G1, reduced cell proliferation and could significantly repress NESTIN/NES, RCOR1/COREST and MECP2. Our results reveal that miR-432 regulate neuronal differentiation of human neuroblastoma cells. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1706 / 1714

页数：9

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