\Mechanisms of age-related macular degeneration and therapeutic opportunities

被引:328
作者
Campagne, Menno van Lookeren [1 ]
LeCouter, Jennifer [2 ]
Yaspan, Brian L. [3 ]
Ye, Weilan [2 ]
机构
[1] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
[2] Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
[3] Genentech Inc, ITGR Human Genet Dept, San Francisco, CA 94080 USA
关键词
age-related macular degeneration (AMD); dry AMD; wet AMD; neovascular AMD (NVAMD); best corrected visual acuity (BCVA); geographic atrophy (GA); choroidal neovascularization (CNV); retinal pigmented epithelial (RPE) cells; COMPLEMENT FACTOR-H; ENDOTHELIAL GROWTH-FACTOR; OCCULT CHOROIDAL NEOVASCULARIZATION; VEGF-TRAP; FACTOR-B; PDGF-B; SUBRETINAL NEOVASCULARIZATION; INTRAVITREAL RANIBIZUMAB; STRONG ASSOCIATION; SUBGROUP ANALYSIS;
D O I
10.1002/path.4266
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
As the age of the population increases in many nations, age-related degenerative diseases pose significant socioeconomic challenges. One of the key degenerative diseases that compromise quality of life is age-related macular degeneration (AMD). AMD is a multi-faceted condition that affects the central retina, which ultimately leads to blindness in millions of people worldwide. The pathophysiology and risk factors for AMD are complex, and the symptoms manifest in multiple related but distinct forms. The ability to develop effective treatments for AMD will depend on a thorough understanding of the underlying pathophysiology, risk factors, and driver molecular pathways, as well as the ability to develop useful animal models. This review provides an overview of the aforementioned aspects in AMD. Copyright (c) 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
引用
收藏
页码:151 / 164
页数:14
相关论文
共 140 条
[1]  
Age-Related Eye Disease Study Research G, 1999, AREDS report no. 1 Control. Clin. Trials, V20, P573, DOI [10.1016/S0197-2456(99)00031-8, DOI 10.1016/S0197-2456(99)00031-8]
[2]   Mechanisms of Age-Related Macular Degeneration [J].
Ambati, Jayakrishna ;
Fowler, Benjamin J. .
NEURON, 2012, 75 (01) :26-39
[3]   Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration [J].
Bhutto, IA ;
McLeod, DS ;
Hasegawa, T ;
Kim, SY ;
Merges, C ;
Tong, P ;
Lutty, GA .
EXPERIMENTAL EYE RESEARCH, 2006, 82 (01) :99-110
[4]   PHYSIOLOGY OF THE CHOROIDAL VASCULAR BED [J].
BILL, A ;
SPERBER, G ;
UJIIE, K .
INTERNATIONAL OPHTHALMOLOGY, 1983, 6 (02) :101-107
[5]   AN INTERNATIONAL CLASSIFICATION AND GRADING SYSTEM FOR AGE-RELATED MACULOPATHY AND AGE-RELATED MACULAR DEGENERATION [J].
BIRD, AEC ;
BRESSLER, NM ;
BRESSLER, SB ;
CHISHOLM, IH ;
COSCAS, G ;
DAVIS, MD ;
DEJONG, PTVM ;
KLAVER, CCW ;
KLEIN, BEK ;
KLEIN, R ;
MITCHELL, P ;
SARKS, JP ;
SARKS, SH ;
SOURBANE, G ;
TAYLOR, HR ;
VINGERLING, JR .
SURVEY OF OPHTHALMOLOGY, 1995, 39 (05) :367-374
[6]   Subgroup analysis of the MARINA study of ranibizumab in neovascular age-related macular degeneration [J].
Boyer, David S. ;
Antoszyk, Andrew N. ;
Awh, Carl C. ;
Bhisitkul, Robert B. ;
Shapiro, Howard ;
Acharya, Nisha R. .
OPHTHALMOLOGY, 2007, 114 (02) :246-252
[7]  
Bressler NM, 2011, ARCH OPHTHALMOL-CHIC, V129, P709, DOI 10.1001/archophthalmol.2011.140
[8]   AGE-RELATED MACULAR DEGENERATION [J].
BRESSLER, NM ;
BRESSLER, SB ;
FINE, SL .
SURVEY OF OPHTHALMOLOGY, 1988, 32 (06) :375-413
[9]   Effects of an anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: Optimizing methods to quantify vascular changes [J].
Campa, Claudio ;
Kasman, Ian ;
Ye, Weilan ;
Lee, P. ;
Fuh, Germaine ;
Ferrara, Napoleone .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2008, 49 (03) :1178-1183
[10]   A Subretinal Matrigel Rat Choroidal Neovascularization (CNV) Model and Inhibition of CNV and Associated Inflammation and Fibrosis by VEGF Trap [J].
Cao, Jingtai ;
Zhao, Lian ;
Li, Yiwen ;
Liu, Yang ;
Xiao, Weihong ;
Song, Ying ;
Luo, Lingyu ;
Huang, Deqiang ;
Yancopoulos, George D. ;
Wiegand, Stanley J. ;
Wen, Rong .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (11) :6009-6017