Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit

被引：17

作者：

Amos, R. ^{[1
]}

Bulbeck, H. ^{[2
]}

Burnet, N. G. ^{[3
,4
,5
]}

Crellin, A. ^{[6
]}

Eaton, D.

Evans, P. ^{[7
,8
]}

Hall, E. ^{[9
]}

Hawkins, M. A. ^{[10
]}

Kirkby, K. J. ^{[3
,4
]}

Mackay, R. ^{[11
]}

Sebag-Montefiore, D. ^{[13
,14
]}

Sharma, R. ^{[12
]}

机构：

[1] UCL, Dept Med Phys & Biomed Engn, Proton & Adv Radiotherapy Grp, London, England

[2] Brainstrust, Cowes, England

[3] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[4] Christie NHS Fdn Trust, Manchester, Lancs, England

[5] Leeds Teaching Hosp Trust, Leeds Canc Ctr, NHS England Natl Clin Lead Proton Beam Therapy, Leeds, W Yorkshire, England

[6] Mt Vernon Hosp, Natl Radiotherapy Trials Qual Assurance Grp RTTQA, Northwood, Middx, England

[7] Univ Surrey, CVSSP, Guildford, Surrey, England

[8] Natl Phys Lab, Teddington, Middx, England

[9] Inst Canc Res, London, England

[10] Univ Oxford, CRUK MRC Oxford Inst Radiat Oncol, Gray Labs, Oxford, England

[11] Christie NHS Fdn Trust, Christie Med Phys & Engn, Manchester, Lancs, England

[12] UCL Canc Inst, NIHR Univ Coll London Hosp Biomed Res Ctr, London, England

[13] Univ Leeds, Radiotherapy Res Grp, Leeds, W Yorkshire, England

[14] Leeds Canc Ctr, Leeds, W Yorkshire, England

来源：

CLINICAL ONCOLOGY | 2018年 / 30卷 / 05期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

Proton beam therapy; external beam radiotherapy; clinical trials; INTENSITY-MODULATED RADIOTHERAPY; CANCER; TRIAL;

D O I：

10.1016/j.clon.2018.02.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials. (C) 2018 Published by Elsevier Ltd on behalf of The Royal College of Radiologists.

引用

页码：280 / 284

页数：5

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