The Course of COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases

被引:9
作者
Rorat, Marta [1 ]
Zarebska-Michaluk, Dorota [2 ]
Kowalska, Justyna [3 ]
Kujawa, Krzysztof [4 ]
Rogalska, Magdalena [5 ]
Kozielewicz, Dorota [6 ]
Lorenc, Beata [7 ]
Sikorska, Katarzyna [8 ,9 ]
Czupryna, Piotr [10 ]
Bolewska, Beata [11 ]
Maciukajc, Jadwiga [12 ]
Piekos, Tomasz [13 ]
Podlasin, Regina [14 ]
Dworzanska, Anna [15 ]
Mazur, Wlodzimierz [16 ]
Brzdek, Michal [2 ]
Szymanek-Pasternak, Anna [17 ]
Flisiak, Robert [5 ]
机构
[1] Wroclaw Med Univ, Dept Forens Med, PL-50367 Wroclaw, Poland
[2] Jan Kochanowski Univ, Dept Infect Dis, PL-25369 Kielce, Poland
[3] Med Univ Warsaw, Dept Adults Infect Dis, PL-02091 Warsaw, Poland
[4] Wroclaw Med Univ, Stat Anal Ctr, PL-50368 Wroclaw, Poland
[5] Med Univ Bialystok, Dept Infect Dis & Hepatol, PL-15089 Bialystok, Poland
[6] Nicolaus Copernicus Univ, Fac Med, Dept Infect Dis & Hepatol, Coll Med Bydgoszcz, PL-87100 Torun, Poland
[7] Pomeranian Ctr Infect Dis, Dept Infect Dis, PL-80210 Gdansk, Poland
[8] Med Univ Gdansk, Fac Hlth Sci, Dept Trop Med & Parasitol, Div Trop Med & Epidemiol, PL-80210 Gdansk, Poland
[9] Med Univ Gdansk, Fac Hlth Sci, Dept Trop Med & Parasitol, Div Trop & Parasit Dis, PL-80210 Gdansk, Poland
[10] Med Univ Bialystok, Dept Infect Dis & Neuroinfect, PL-15089 Bialystok, Poland
[11] Poznan Univ Med Sci, Dept Infect Dis, PL-61701 Poznan, Poland
[12] Dist Healthcare Ctr, Dept Infect Dis, PL-27200 Starachowice, Poland
[13] Independent Publ Healthcare Ctr Pulawy, Dept Infect Dis & Observat Adults, PL-24100 Pulawy, Poland
[14] Hosp Infect Dis, Dept 4, PL-01301 Warsaw, Poland
[15] Med Univ Lublin, Dept Infect Dis & Hepatol, PL-20059 Lublin, Poland
[16] Med Univ Silesiaia, Clin Dept Infect Dis Chorzow, PL-41500 Katowice, Poland
[17] Wroclaw Med Univ, Dept Infect Dis & Hepatol, PL-50367 Wroclaw, Poland
关键词
connective tissue diseases; remdesivir; immunodeficiency; respiratory failure; OUTCOMES;
D O I
10.3390/jcm11247342
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Patients with systemic autoimmune rheumatic disease (SARD) have increased susceptibility to viral infections, including SARS-CoV-2. The aim of this study was to analyse the SARD patient population with COVID-19 (coronavirus disease 2019) in terms of baseline characteristics, severity, course and outcomes of the disease compared with the non-SARD group, and to identify factors associated with prognosis, including remdesivir therapy efficacy. Retrospective study comprised 8220 COVID-19 cases from the SARSTer database, including 185 with SARD. Length of hospitalisation, duration of oxygen therapy, mortality and the need for HFNO (high-flow nasal oxygen) and/or NIV (noninvasive ventilation) were significantly higher in the SARD versus non-SARD group. There was no difference in clinical features on admission to hospital. Patients with SARD were older and more likely to have cardiovascular, pulmonary and chronic kidney diseases. Age, the presence of cardiovascular disease, more severe conditions on admission and higher inflammatory marker values were found to be risk factors for death in the SARD group. In patients with SARD treated with remdesivir, there was a trend towards improved mortality but without statistical significance. Length of hospitalisation, 28-day mortality and the need for HFNO and/or NIV were higher in the SARD group. These patients often had other chronic diseases and were older.
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