Leptin receptor of Zucker fatty rat performs reduced signal transduction

被引：107

作者：

Yamashita, T

Murakami, T

Iida, M

Kuwajima, M

Shima, K

机构：

[1] UNIV TOKUSHIMA,SCH MED,DEPT INTERNAL MED,TOKUSHIMA 770,JAPAN

[2] OTSUKA PHARMACEUT CO LTD,OTSUKA ASSAY LABS,TOKUSHIMA,JAPAN

[3] OTSUKA PHARMACEUT CO LTD,TOKUSHIMA INST NEW DRUG RES 2,TOKUSHIMA,JAPAN

来源：

DIABETES | 1997年 / 46卷 / 06期

关键词：

D O I：

10.2337/diabetes.46.6.1077

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Zucker fatty (fa/fa) rats exhibit overt obesity, hypercholesterolemia, hyperlipidemia, and hyperglycemia as recessive traits. The fa mutation has been determined to be a missense mutation in the extracellular domain of the leptin receptor. We report herein the construction of CHO cells that stably express the fa-type leptin receptor and the characterization of this receptor using mRNA expression levels of the immediate early genes, c-fos, c-jun, and jun-B, which are induced by leptin as a criterion of signal transduction. The fa-type receptor not only exhibits a slightly reduced leptin-binding affinity, but also performs reduced signal transduction.

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页码：1077 / 1080

页数：4

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