Study of artemisinin nanocapsules as anticancer drug delivery systems

被引：106

作者：

Chen, Youfang ^{[1
]}

Lin, Xianfu ^{[1
]}

Park, Hyunjin ^{[2
]}

Greever, Richard ^{[3
]}

机构：

[1] Zhejiang Univ, Inst Appl Chem, Dept Chem, Hangzhou 310003, Zhejiang, Peoples R China

[2] Korea Univ, Grad Sch Biotechnol, Seoul, South Korea

[3] Korea Fdn Adv Studies, Seoul, South Korea

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2009年 / 5卷 / 03期

关键词：

Nanoencapsulation; Controlled release; Artemisinin; MULTILAYER FILM MORPHOLOGY; RELEASE PROPERTIES; POLYELECTROLYTES; MICROPARTICLES; ENCAPSULATION;

D O I：

10.1016/j.nano.2008.12.005

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Artemisinin (ART) crystals were encapsulated with chitosan, gelatin, and alginate for the purpose of controlled release. These polyelectrolytes were alternatively deposited on ART crystals sized about 766 nm through the layer-by-layer technique. Size distribution, zeta potential, and swelling property of ART nanocapsules were measured. The morphology of ART nanocapsules was observed by transmission electron microscopy after dissolution. Release property of ART nanocapsules was measured in phosphate buffer solution (pH 7.4). It was proved that the ART nanocapsules dispersed well in aqueous solutions. Hydrophilicity of ART crystals was improved after encapsulation. The ART drug release rate was tuned by the properties of polyelectrolyte solutions, such as polyelectrolyte type, number of polyelectrolyte multilayers, sodium chloride concentration, and ethanol concentration in polyelectrolyte solution, and so on. Our research provides a feasible method of achieving prolonged drug release through self-assembly of polyelectrolytes on natural drug crystals.

引用

页码：316 / 322

页数：7

共 22 条

[11] A dosage design of mitomycin C tablets containing finely powdered green tea [J].

Kurita, T ;

Miyagishima, A ;

Nozawa, Y ;

Sadzuka, Y ;

Sonobe, T .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2004, 275 (1-2) :279-283

[12]

LI G, 2000, PHARM J CLIN PLA, V1, P15

[13] Urease encapsulation in nanoorganized microshells [J].

Lvov, Y ;

Antipov, AA ;

Mamedov, A ;

Möhwald, H ;

Sukhorukov, GB .

NANO LETTERS, 2001, 1 (03) :125-128

[14] Atomic force microscopy studies of salt effects on polyelectrolyte multilayer film morphology [J].

McAloney, RA ;

Sinyor, M ;

Dudnik, V ;

Goh, MC .

LANGMUIR, 2001, 17 (21) :6655-6663

[15] Kinetics of salt-induced annealing of a polyelectrolyte multilayer film morphology [J].

McAloney, RA ;

Dudnik, V ;

Goh, MC .

LANGMUIR, 2003, 19 (09) :3947-3952

[16] Optical and electrical characterisation of polyelectrolyte self-assembled thin films [J].

Nabok, AV ;

Hassan, AK ;

Ray, AK .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 1999, 8-9 :505-508

[17] Studies on the drug release properties of polysaccharide multilayers encapsulated ibuprofen microparticles [J].

Qiu, XP ;

Leporatti, S ;

Donath, E ;

Möhwald, H .

LANGMUIR, 2001, 17 (17) :5375-5380

[18] Layer by layer buildup of polysaccharide films: Physical chemistry and cellular adhesion aspects [J].

Richert, L ;

Lavalle, P ;

Payan, E ;

Shu, XZ ;

Prestwich, GD ;

Stoltz, JF ;

Schaaf, P ;

Voegel, JC ;

Picart, C .

LANGMUIR, 2004, 20 (02) :448-458

[19] Ultrathin self-assembled polyelectrolyte multilayer membranes [J].

Tieke, B ;

van Ackern, F ;

Krasemann, L ;

Toutianoush, A .

EUROPEAN PHYSICAL JOURNAL E, 2001, 5 (01) :29-39

[20] Sequentially adsorbed electrostatic multilayers of branched side-chain polyelectrolytes bearing donor-acceptor type Azo chromophores [J].

Wang, HP ;

He, YN ;

Tuo, XL ;

Wang, XG .

MACROMOLECULES, 2004, 37 (01) :135-146

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