Alginate-based bipolymeric-nanobioceramic composite matrices for sustained drug release

被引：43

作者：

Hasnain, M. Saquib ^{[1
]}

Nayak, Amit Kumar ^{[2
]}

Singh, Mukul ^{[3
]}

Tabish, Mohammad ^{[4
]}

Ansari, Mohammed Tahir ^{[5
]}

Ara, Tahseen Jahan ^{[6
]}

机构：

[1] Shri Venkateshwara Univ, Dept Pharm, NH 24, Amroha 244236, UP, India

[2] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut, Mayurbhanj 757086, Odisha, India

[3] Shivdan Singh Inst Technol & Management, Dept Pharm, Aligarh 202002, Uttar Pradesh, India

[4] Shaqra Univ, Coll Med, Riyadh, Saudi Arabia

[5] Univ Kuala Lumpur, Royal Coll Med, Fac Pharm & Hlth Sci, Perak, Ipoh, Malaysia

[6] LNM Univ, Dept Chem, Darbhanga, Bihar, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2016年 / 83卷

关键词：

Alginate; Nano-hydroxyapatite; Drug release; DICLOFENAC SODIUM; DELIVERY-SYSTEM; BEADS; OPTIMIZATION; CELLULOSE; HYDROXYAPATITE; MICROSPHERES; GLICLAZIDE; MICROBEADS; CHITOSAN;

D O I：

10.1016/j.ijbiomac.2015.11.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alginate-based bipolymeric-nanobioceramic composite matrices for sustained drug release were developed through incorporation of nano-hydroxyapatite [nHAp] powders within ionotropically-gelled calcium ion-induced alginate-poly (vinyl pyrrolidone) blends polymeric systems. nHAp powders were synthesized by precipitation technique using calcium hydroxide [Ca(OH)(2)] and orthophosphoric acid [H3PO4] as raw materials. The average particle size of these was synthesized. nHAp powders was found as 19.04 nm and used to prepare nHAp-alginate-PVP beads containing DS. These beads exhibited drug entrapment efficiency (%) of 65.82 +/- 1.88 to 94.45 +/- 3.72% and average bead sizes of 0.98 +/- 0.07 to 1.23 +/- 0.15 mm. These beads were characterized by scanning electron microscopy (SEM) and Fourier transform-infra red (FTIR) spectroscopy analyses. Various nHAp-alginate-PVP beads containing DS exhibited prolonged sustained drug release and followed the Koresmeyer-Peppas model of drug release (R-2 = 0.9908-0.9978) with non-Fickian release (anomalous transport) mechanism (n = 0.73-0.84) for drug release over 8 h. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：71 / 77

页数：7

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