Clarifying the role of EMSY in DNA repair in ovarian cancer

被引：8

作者：

Kondrashova, Olga ^{[1
,2
]}

Scott, Clare L. ^{[1
,3
,4
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Canc Biol & Stem Cells Div, Melbourne, Vic, Australia

[2] QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, Brisbane, Qld, Australia

[3] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[4] Univ Melbourne, Royal Womens Hosp, Melbourne, Vic, Australia

来源：

CANCER | 2019年 / 125卷 / 16期

基金：

英国医学研究理事会;

关键词：

DNA repair; EMSY amplification; EMSY overexpression; homologous recombination; ovarian cancer; PARP inhibitors; AMPLIFICATION; BREAST; 11Q13; GENE; RECRUITMENT; EXPRESSION; ONCOGENE; PATHWAY; DAMAGE;

D O I：

10.1002/cncr.32135

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although evidence supports the involvement of EMSY in DNA repair, EMSY amplification fails to suppress RAD51 foci formation, a marker of homologous recombination DNA repair. The majority of analyses to date have been performed in cell lines. Models more closely representing patients should be studied to determine the relevance of EMSY for use as a predictive biomarker for response to platinum and poly (adenosine diphosphate ribose) polymerase inhibitor therapy.

引用

页码：2720 / 2724

页数：5

共 24 条

[1] Expression of EMSY gene in sporadic ovarian cancer [J].

Altinisik, Julide ;

Karateke, Ates ;

Coksuer, Hakan ;

Ulutin, Turgut ;

Buyru, Nur .

MOLECULAR BIOLOGY REPORTS, 2011, 38 (01) :359-363

[2] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[3]

Bertwistle D, 1997, CANCER RES, V57, P5485

[4] Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas [J].

Brown, LA ;

Irving, J ;

Parker, R ;

Kim, H ;

Press, JZ ;

Longacre, TA ;

Chia, S ;

Magliocco, A ;

Makretsov, N ;

Gilks, B ;

Pollack, J ;

Huntsman, D .

GYNECOLOGIC ONCOLOGY, 2006, 100 (02) :264-270

[5] Amplification of 11q13 in ovarian carcinoma [J].

Brown, Lindsay A. ;

Kalloger, Steve E. ;

Miller, Melinda A. ;

Shih, le-Ming ;

McKinney, Steven E. ;

Santos, Jennifer L. ;

Swenerton, Ken ;

Spellman, Paul T. ;

Gray, Joe ;

Gilks, C. Blake ;

Huntsman, David G. .

GENES CHROMOSOMES & CANCER, 2008, 47 (06) :481-489

[6] Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers [J].

Brown, Lindsay A. ;

Johnson, Karynn ;

Leung, Samuel ;

Bismar, Tarek A. ;

Benitez, Javier ;

Foulkes, William D. ;

Huntsman, David G. .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 121 (02) :347-354

[7] EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases [J].

Cousineau, Isabelle ;

Belmaaza, Abdellah .

MOLECULAR GENETICS AND GENOMICS, 2011, 285 (04) :325-340

[8]

Dansonka-Mieszkowska Agnieszka, 2018, Oncotarget, V9, P17735, DOI 10.18632/oncotarget.24878

[9] Binding of EMSY to HP1β:: implications for recruitment of HP1β and BS69 [J].

Ekblad, CMS ;

Chavali, GB ;

Basu, BP ;

Freund, SMV ;

Veprintsev, D ;

Hughes-Davies, L ;

Kouzarides, T ;

Doherty, AJ ;

Itzhaki, LS .

EMBO REPORTS, 2005, 6 (07) :675-680

[10] The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY [J].

Ezella, Scott A. ;

Polytarchou, Christos ;

Hatziapostolou, Maria ;

Guo, Ailan ;

Sanidas, Ioannis ;

Bihani, Teeru ;

Comb, Michael J. ;

Sourvinos, George ;

Tsichlis, Philip N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (10) :E613-E621

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