The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery

被引：45

作者：

Cheung, C. W. ^{[1
]}

Qiu, Q. ^{[1
]}

Ying, A. C. L. ^{[3
]}

Choi, S. W. ^{[1
]}

Law, W. L. ^{[2
]}

Irwin, M. G. ^{[1
]}

机构：

[1] Univ Hong Kong, Lab & Clin Res Inst Pain, Dept Anaesthesiol, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China

[3] Prince Wales Hosp, Dept Anaesthesia & Intens Care, Hong Kong, Hong Kong, Peoples R China

来源：

ANAESTHESIA | 2014年 / 69卷 / 11期

关键词：

RANDOMIZED CONTROLLED-TRIALS; INTRAVENOUS DEXMEDETOMIDINE; MORPHINE; MANAGEMENT; ANALGESIA; AGONISTS; PATIENT; METAANALYSIS; INFUSION; EFFICACY;

D O I：

10.1111/anae.12759

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

In this double-blind, randomised study, 100 patients undergoing open or conventional laparoscopic colorectal surgery received an intra-operative loading dose of dexmedetomidine 1g.kg(-1) followed by an infusion of 0.5g.kg(-1).h(-1), or a bolus and infusion of saline 0.9% of equivalent volume. Forty-six patients in the dexmedetomidine group and 50 in the saline group completed the study. The area under the curve of numerical rating scores for pain at rest for 1-48h postoperatively was significantly lower in the patients receiving dexmedetomidine (p=0.041). There was no difference in morphine consumption, duration of recovery ward or hospital stay. From the data obtained in this study, we calculated a number needed to treat for effective pain relief of 4. Intra-operative dexmedetomidine in colorectal surgery resulted in a reduction in resting pain scores, but there was no morphine-sparing effect or improvement in patients' recovery outcome measures.

引用

页码：1214 / 1221

页数：8

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