Bioactive Diterpenoids from Clerodendrum kiangsiense

被引：10

作者：

Xu, Mingfeng ^{[1
]}

Wang, Shengjia ^{[1
]}

Jia, Ouya ^{[1
]}

Zhu, Qin ^{[1
]}

Shi, Lu'e ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Zhejiang Prov Key Lab Genet Improvement & Qual Co, Hangzhou 310036, Zhejiang, Peoples R China

来源：

MOLECULES | 2016年 / 21卷 / 01期

关键词：

Clerodendrum kiangsiense; abeo-abietane diterpenoid; cytotoxicity; ABIETANE DITERPENOIDS; CONSTITUENTS; GLYCOSIDES; LEAVES; ROOTS;

D O I：

10.3390/molecules21010086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(1516)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (1-7). Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HL-60, SMMC-7721, A-549 and MCF-7 by the MTT assay. The results showed that cryptojaponol (4), fortunin E (6) and 8 exhibited significant cytotoxicity against four human cancer cell lines.

引用

页数：6

共 19 条

[1] New flavonoid glycosides and other chemical constituents from Clerodendrum phlomidis leaves: isolation and characterisation [J].

Bharitkar, Yogesh P. ;

Hazra, Abhijit ;

Shah, Siddharth ;

Saha, Sudeshna ;

Matoori, Anil Kumar ;

Mondal, Nirup B. .

NATURAL PRODUCT RESEARCH, 2015, 29 (19) :1850-1856

[2] Isolation and Identification of Cytotoxic Compounds from Aeschynomene fascicularis, a Mayan Medicinal Plant [J].

Caamal-Fuentes, Edgar E. ;

Peraza-Sanchez, Sergio R. ;

Torres-Tapia, Luis W. ;

Moo-Puc, Rosa E. .

MOLECULES, 2015, 20 (08) :13563-13574

[3] In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica [J].

Fronza, M. ;

Murillo, R. ;

Slusarczyk, S. ;

Adams, M. ;

Hamburger, M. ;

Heinzmann, B. ;

Laufer, S. ;

Merfort, I. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (16) :4876-4881

[4] New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities [J].

Gazim, Zilda Cristiani ;

Rodrigues, Felipe ;

Lourenco Amorin, Ana Carolina ;

de Rezende, Claudia Moraes ;

Sokovic, Marina ;

Tesevic, Vele ;

Vuckovic, Ivan ;

Krstic, Gordana ;

Ranieri Cortez, Lucia Elaine ;

Colauto, Nelson Barros ;

Linde, Giani Andrea ;

Garcia Cortez, Diogenes Aparicio .

MOLECULES, 2014, 19 (01) :514-524

[5] Abietane Diterpenoids and a Sesquiterpene Pyridine Alkaloid from Euonymus Iutchuensis [J].

Inaba, Yasunori ;

Hasuda, Tomoyo ;

Hitotsuyanagi, Yukio ;

Aoyagi, Yutaka ;

Fujikawa, Naoko ;

Onozaki, Ayana ;

Watanabe, Ayumi ;

Kinoshita, Takeshi ;

Takeya, Koichi .

JOURNAL OF NATURAL PRODUCTS, 2013, 76 (06) :1085-1090

[6] Antioxidant activities of abietane diterpenoids isolated from Torreya nucifera leaves [J].

Lee, Woo Song ;

Kim, Ju-Ryoung ;

Han, Jong-Min ;

Jang, Ki Chang ;

Sok, Dai-Eun ;

Jeong, Tae-Sook .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (15) :5369-5374

[7] An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus [J].

Liang, Zizhen ;

Zhang, Tiantian ;

Zhang, Xiaoqian ;

Zhang, Jia ;

Zhao, Changqi .

MOLECULES, 2015, 20 (01) :1424-1433

[8] Diterpenoids and phenylethanoid glycosides from the roots of Clerodendrum bungei and their inhibitory effects against angiotensin converting enzyme and α-glucosidase [J].

Liu, Qing ;

Hu, Hai-Jun ;

Li, Peng-Fei ;

Yang, Ying-Bo ;

Wu, Li-Hong ;

Chou, Gui-Xin ;

Wang, Zheng-Tao .

PHYTOCHEMISTRY, 2014, 103 :196-202

[9]

MIN Z D, 1989, Yaoxue Xuebao, V24, P673

[10] Anti-inflammatory and antipyretic properties of Clerodendrum petasites S.!Moore [J].

Panthong, A ;

Kanjanapothi, D ;

Taesotikul, T ;

Wongcome, T ;

Reutrakul, V .

JOURNAL OF ETHNOPHARMACOLOGY, 2003, 85 (01) :151-156

← 1 2 →