Sensing pathogens and danger signals by the inflammasome

被引：200
作者：
Pedra, Joao H. F. [1 ,2 ,3 ]
Cassel, Suzanne L.
Sutterwala, Fayyaz S. [4 ,5 ]
机构：
[1] Univ Calif Riverside, Inst Integrat Genome Biol, Riverside, CA 92521 USA
[2] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA
[3] Yale Univ, Sch Med, Dept Internal Med, Infect Dis Sect, New Haven, CT 06520 USA
[4] Univ Iowa, Dept Internal Med, Inflammat Program, Iowa City, IA 52241 USA
[5] Univ Iowa, Dept Internal Med, Div Infect Dis, Iowa City, IA 52241 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 01期
基金：
美国国家卫生研究院;
关键词：
MUCKLE-WELLS-SYNDROME; LEGIONELLA-PNEUMOPHILA INFECTION; COLD AUTOINFLAMMATORY SYNDROME; PATTERN-RECOGNITION RECEPTORS; INNATE IMMUNE-RESPONSE; NALP3; INFLAMMASOME; CASPASE-1; ACTIVATION; INTERLEUKIN-1-BETA RELEASE; IL-1-BETA SECRETION; DENDRITIC CELLS;
D O I：
10.1016/j.coi.2009.01.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The NLR (nucleotide-binding domain leucine-rich repeat containing) family of intracellular sensors is a crucial component of the innate immune system. A number of NLR family members can form multiprotein complexes, called inflammasomes, and are capable of activating the cysteine protease caspase-1 in response to a wide range of stimuli including both microbial and self-molecules. Caspase-1 activation leads to processing and secretion of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18, which play crucial roles in host defense to infectious insults. Dysregulation of the inflammasome has also been linked to a number of autoinflammatory and autoimmune disorders. Recent advances in the inflammasome field will be discussed in this review.
引用
收藏
页码：10 / 16
页数：7
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