Anosognosia for hemiplegia as a tripartite disconnection syndrome

被引：72

作者：

Pacella, Valentina ^{[1
,2
]}

Foulon, Chris ^{[3
,4
,5
]}

Jenkinson, Paul M. ^{[6
]}

Scandola, Michele ^{[2
]}

Bertagnoli, Sara ^{[2
]}

Avesani, Renato ^{[7
]}

Fotopoulou, Aikaterini ^{[8
]}

Moro, Valentina ^{[2
]}

de Schotten, Michel Thiebaut ^{[3
,4
,9
]}

机构：

[1] Sapienza Univ Rome, Dept Psychol, Social & Cognit Neurosci Lab, Rome, Italy

[2] Univ Verona, Dept Human Sci, NPSY Lab VR, Verona, Italy

[3] Sorbonne Univ, Brain Connect & Behav Lab, Paris, France

[4] UPMC, UMRS 1127, Frontlab,UMR 7225, Inst Cerveau & Moelle Epiniere ICM,INSERM,U1127,C, Paris, France

[5] Univ Texas Austin, Computat Neuroimaging Lab, Dept Diagnost Med, Dell Med Sch, Austin, TX 78712 USA

[6] Univ Hertfordshire, Sch Life & Med Sci, Hatfield, Herts, England

[7] IRCSS Sacro Cuore Don Calabria Hosp, Dept Rehabil, Verona, Italy

[8] UCL, Clin Educ & Hlth Psychol, Div Psychol & Language Sci, London, England

[9] Univ Bordeaux, Grp Imagerie Neurofonct, Inst Malad Neurodegenerat, UMR 5293,CNRS,CEA, Bordeaux, France

来源：

ELIFE | 2019年 / 8卷

基金：

欧盟地平线“2020”;

关键词：

MOTOR AWARENESS; IMPLICIT AWARENESS; RIGHT-HEMISPHERE; HUMAN BRAIN; UNAWARENESS; VARIABILITY; REGIONS; LESIONS; SYSTEM;

D O I：

10.7554/eLife.46075

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.

引用

页数：13

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