Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM

被引：72

作者：

Takeshita, T

Arita, T

Asao, H

Tanaka, N

Higuchi, M

Kuroda, H

Kaneko, K

Munakata, H

Endo, Y

Fujita, T

Sugamura, K

机构：

[1] TOHOKU UNIV,SCH MED,DEPT MICROBIOL,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

[2] TOHOKU UNIV,SCH MED,DEPT BIOCHEM,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

[3] FUKUSHIMA MED COLL,DEPT BIOCHEM,FUKUSHIMA 96012,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 225卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1006/bbrc.1996.1290

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors. (C) 1996 Academic Press, Inc.

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收藏

页码：1035 / 1039

页数：5

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