Environmental control of Th17 differentiation

被引：20

作者：

Quintana, Francisco J. ^{[1
]}

Weiner, Howard L. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 03期

关键词：

Diet; Environment; Microbes; Th17; Toxins; ARYL-HYDROCARBON-RECEPTOR; T(H)17 CELL-DIFFERENTIATION; T-CELLS; ACTIVATION; INTERLEUKIN-27; CD4(+)CD25(+); EXPRESSION; INDUCTION; IMMUNITY;

D O I：

10.1002/eji.200839198

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th17 cells participate in the control of extracellular bacteria and fungi, but dysregulated Th17 cell activity can result in immunopathology. Thus, the generation and the activity of Th17 cells should be tightly regulated, and simultaneously it should be able to respond to the challenges presented by a changing environment. in this viewpoint, we discuss some of the mechanisms by which microbes, dietary components and environmental toxins influence the Th17 response.

引用

页码：655 / 657

页数：3

共 36 条

[1] ATP drives lamina propria TH17 cell differentiation [J].

Atarashi, Koji ;

Nishimura, Junichi ;

Shima, Tatsuichiro ;

Umesaki, Yoshinori ;

Yamamoto, Masahiro ;

Onoue, Masaharu ;

Yagita, Hideo ;

Ishii, Naoto ;

Evans, Richard ;

Honda, Kenya ;

Takeda, Kiyoshi .

NATURE, 2008, 455 (7214) :808-U10

[2]

AWASTHI A, 2007, NAT IMMUNOL

[3] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[4] Induction and effector functions of TH17 cells [J].

Bettelli, Estelle ;

Korn, Thomas ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE, 2008, 453 (7198) :1051-1057

[5] Ligand-independent regulation of transforming growth factor β1 expression and cell cycle progression by the aryl hydrocarbon receptor [J].

Chang, Xiaoqing ;

Fan, Yunxia ;

Karyala, Saikumar ;

Schwemberger, Sandy ;

Tomlinson, Craig R. ;

Sartor, Maureen A. ;

Puga, Alvaro .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (17) :6127-6139

[6] Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile [J].

Daniel, Carolin ;

Sartory, Nico A. ;

Zahn, Nadine ;

Radeke, Heinfried H. ;

Stein, Jurgen M. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 324 (01) :23-33

[7] Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses [J].

Denning, Timothy L. ;

Wang, Yi-Chong ;

Patel, Seema R. ;

Williams, Ifor R. ;

Pulendran, Bali .

NATURE IMMUNOLOGY, 2007, 8 (10) :1086-1094

[8] Cutting edge:: Activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+CD25+ cells with characteristics of regulatory T cells [J].

Funatake, CJ ;

Marshall, NB ;

Steppan, LB ;

Mourich, DV ;

Kerkvliet, NI .

JOURNAL OF IMMUNOLOGY, 2005, 175 (07) :4184-4188

[9] Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+, cells in the draining lymph nodes [J].

Gorman, Shelley ;

Kuritzky, L. Alexandra ;

Judge, Melinda A. ;

Dixon, Katie M. ;

McGlade, Jacqueline P. ;

Mason, Rebecca S. ;

Finlay-Jones, John J. ;

Hart, Prue H. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (09) :6273-6283

[10] Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses [J].

Hall, Jason A. ;

Bouladoux, Nicolas ;

Sun, Cheng Ming ;

Wohlfert, Elizabeth A. ;

Blank, Rebecca B. ;

Zhu, Qing ;

Grigg, Michael E. ;

Berzofsky, Jay A. ;

Belkaid, Yasmine .

IMMUNITY, 2008, 29 (04) :637-649

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