共 36 条
Improved Detection of Small Pulmonary Nodules Through Simultaneous MR/PET Imaging
被引:4
作者:

Boada, Fernando E.
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机构:
NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA

Koesters, Thomas
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h-index: 0
机构:
NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA

Block, Kai Tobias
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机构:
NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA

Chandarana, Hersh
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h-index: 0
机构:
NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA
机构:
[1] NYU, Dept Radiol, Langone Med Ctr, Ctr Adv Imaging Innovat & Res, 660 First Ave, New York, NY 10016 USA
关键词:
MR/PET;
Lung nodule;
Motion correction;
RESPIRATORY MOTION CORRECTION;
ATTENUATION CORRECTION;
ONCOLOGY APPLICATIONS;
PET/CT;
MRI;
PET/MRI;
IMAGES;
RECONSTRUCTION;
COMPENSATION;
SCANNER;
D O I:
10.1016/j.mric.2016.12.009
中图分类号:
R8 [特种医学];
R445 [影像诊断学];
学科分类号:
1002 ;
100207 ;
1009 ;
摘要:
Magnetic resonance (MR)/PET scanners provide an imaging platform that enables simultaneous acquisition of MR and PET data in perfect spatial and temporal registration. This feature allows improving image quality for the MR and PET images obtained during the course of an examination. In this work the authors demonstrate the use of prospective MR-based motion tracking information for removing motion blur in MR/PET images of small pulmonary nodules. The theoretical basis for the algorithms is presented alongside clinical examples of its use.
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页码:273 / +
页数:9
相关论文
共 36 条
[1]
Combined correction of recovery effect and motion blur for SUV quantification of solitary pulmonary nodules in FDG PET/CT
[J].
Apostolova, Ivayla
;
Wiemker, Rafael
;
Paulus, Timo
;
Kabus, Sven
;
Dreilich, Thomas
;
van den Hoff, Joerg
;
Plotkin, Michail
;
Mester, Janos
;
Brenner, Winfried
;
Buchert, Ralph
;
Klutmann, Susanne
.
EUROPEAN RADIOLOGY,
2010, 20 (08)
:1868-1877

Apostolova, Ivayla
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Wiemker, Rafael
论文数: 0 引用数: 0
h-index: 0
机构:
Philips Res Europe, Hamburg, Germany
Philips Res Europe, Aachen, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Paulus, Timo
论文数: 0 引用数: 0
h-index: 0
机构:
Philips Res Europe, Hamburg, Germany
Philips Res Europe, Aachen, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Kabus, Sven
论文数: 0 引用数: 0
h-index: 0
机构:
Philips Res Europe, Hamburg, Germany
Philips Res Europe, Aachen, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Dreilich, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Hamburg Eppendorf, Dept Nucl Med, Hamburg, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

van den Hoff, Joerg
论文数: 0 引用数: 0
h-index: 0
机构:
Res Ctr Rossendorf, Inst Radiopharm, PET Ctr, Dresden, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Plotkin, Michail
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Mester, Janos
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Hamburg Eppendorf, Dept Nucl Med, Hamburg, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Brenner, Winfried
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Buchert, Ralph
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany
Univ Med Ctr Hamburg Eppendorf, Dept Nucl Med, Hamburg, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany

Klutmann, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Hamburg Eppendorf, Dept Nucl Med, Hamburg, Germany Charite, Campus Charite Mitte, Dept Nucl Med, D-13353 Berlin, Germany
[2]
Motion Correction and Attenuation Correction for Respiratory Gated PET Images
[J].
Bai, Wenjia
;
Brady, Michael
.
IEEE TRANSACTIONS ON MEDICAL IMAGING,
2011, 30 (02)
:351-365

Bai, Wenjia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Engn Sci, Wolfson Med Vis Lab, Oxford OX1 3PJ, England Univ Oxford, Dept Engn Sci, Wolfson Med Vis Lab, Oxford OX1 3PJ, England

Brady, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Engn Sci, Wolfson Med Vis Lab, Oxford OX1 3PJ, England Univ Oxford, Dept Engn Sci, Wolfson Med Vis Lab, Oxford OX1 3PJ, England
[3]
Respiratory motion correction of PET using MR-constrained PET-PET registration
[J].
Balfour, Daniel R.
;
Marsden, Paul K.
;
Polycarpou, Irene
;
Kolbitsch, Christoph
;
King, Andrew P.
.
BIOMEDICAL ENGINEERING ONLINE,
2015, 14

Balfour, Daniel R.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Rayne Inst, St Thomas Hosp, London, England Kings Coll London, Rayne Inst, St Thomas Hosp, London, England

Marsden, Paul K.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Rayne Inst, St Thomas Hosp, London, England Kings Coll London, Rayne Inst, St Thomas Hosp, London, England

论文数: 引用数:
h-index:
机构:

Kolbitsch, Christoph
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Rayne Inst, St Thomas Hosp, London, England Kings Coll London, Rayne Inst, St Thomas Hosp, London, England

King, Andrew P.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Rayne Inst, St Thomas Hosp, London, England Kings Coll London, Rayne Inst, St Thomas Hosp, London, England
[4]
Value of PET/CT Imaging for Diagnosing Pulmonary Metastasis of Colorectal Cancer
[J].
Bamba, Yoshiko
;
Itabashi, Michio
;
Kameoka, Shingo
.
HEPATO-GASTROENTEROLOGY,
2011, 58 (112)
:1972-1974

Bamba, Yoshiko
论文数: 0 引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Surg 2, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ, Dept Surg 2, Shinjuku Ku, Tokyo 1628666, Japan

Itabashi, Michio
论文数: 0 引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Surg 2, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ, Dept Surg 2, Shinjuku Ku, Tokyo 1628666, Japan

Kameoka, Shingo
论文数: 0 引用数: 0
h-index: 0
机构:
Tokyo Womens Med Univ, Dept Surg 2, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ, Dept Surg 2, Shinjuku Ku, Tokyo 1628666, Japan
[5]
Small pulmonary nodules: Detection at chest CT and outcome
[J].
Benjamin, MS
;
Drucker, EA
;
McLoud, TC
;
Shepard, JAO
.
RADIOLOGY,
2003, 226 (02)
:489-493

Benjamin, MS
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

Drucker, EA
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

McLoud, TC
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

Shepard, JAO
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
[6]
Motion Correction Options in PET/MRI
[J].
Catana, Ciprian
.
SEMINARS IN NUCLEAR MEDICINE,
2015, 45 (03)
:212-223

Catana, Ciprian
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol,Athinoula A Martinos Ctr Biomed Imagi, Charlestown, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol,Athinoula A Martinos Ctr Biomed Imagi, Charlestown, MA 02129 USA
[7]
MRI-Assisted PET Motion Correction for Neurologic Studies in an Integrated MR-PET Scanner
[J].
Catana, Ciprian
;
Benner, Thomas
;
van der Kouwe, Andre
;
Byars, Larry
;
Hamm, Michael
;
Chonde, Daniel B.
;
Michel, Christian J.
;
El Fakhri, Georges
;
Schmand, Matthias
;
Sorensen, Gregory
.
JOURNAL OF NUCLEAR MEDICINE,
2011, 52 (01)
:154-161

Catana, Ciprian
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Charlestown, MA USA Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

Benner, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Charlestown, MA USA Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

van der Kouwe, Andre
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Charlestown, MA USA Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

Byars, Larry
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

Hamm, Michael
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

Chonde, Daniel B.
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Charlestown, MA USA Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

Michel, Christian J.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

El Fakhri, Georges
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

Schmand, Matthias
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

Sorensen, Gregory
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Charlestown, MA USA Massachusetts Gen Hosp, Dept Radiol, Athinoula A Marinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[8]
Event-by-event respiratory motion correction for PET with 3D internal-1D external motion correlation
[J].
Chan, Chung
;
Jin, Xiao
;
Fung, Edward K.
;
Naganawa, Mika
;
Mulnix, Tim
;
Carson, Richard E.
;
Liu, Chi
.
MEDICAL PHYSICS,
2013, 40 (11)

Chan, Chung
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA

Jin, Xiao
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA
Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA

Fung, Edward K.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA
Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA

论文数: 引用数:
h-index:
机构:

Mulnix, Tim
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA

Carson, Richard E.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA
Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA

Liu, Chi
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA
Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA Yale Univ, Dept Diagnost Radiol, Yale PET Ctr, Sch Med, New Haven, CT 06520 USA
[9]
Pulmonary Nodules in Patients with Primary Malignancy: Comparison of Hybrid PET/MR and PET/CT Imaging
[J].
Chandarana, Hersh
;
Heacock, Laura
;
Rakheja, Rajan
;
DeMello, Linda R.
;
Bonavita, John
;
Block, Tobias K.
;
Geppert, Christian
;
Babb, James S.
;
Friedman, Kent P.
.
RADIOLOGY,
2013, 268 (03)
:874-881

Chandarana, Hersh
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA

Heacock, Laura
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA

Rakheja, Rajan
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA

DeMello, Linda R.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA
New York Med Coll, Valhalla, NY 10595 USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA

Bonavita, John
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA

Block, Tobias K.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA

Geppert, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Siemens Healthcare, MR Res & Dev Collaborat, New York, NY USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA

Babb, James S.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA

Friedman, Kent P.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA NYU, Langone Med Ctr, Dept Radiol, New York, NY 10016 USA
[10]
MRI-Based Nonrigid Motion Correction in Simultaneous PET/MRI
[J].
Chun, Se Young
;
Reese, Timothy G.
;
Ouyang, Jinsong
;
Guerin, Bastien
;
Catana, Ciprian
;
Zhu, Xuping
;
Alpert, Nathaniel M.
;
El Fakhri, Georges
.
JOURNAL OF NUCLEAR MEDICINE,
2012, 53 (08)
:1284-1291

Chun, Se Young
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA

Reese, Timothy G.
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, AA Martinos Ctr, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA

Ouyang, Jinsong
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA

Guerin, Bastien
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA

Catana, Ciprian
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, AA Martinos Ctr, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA

Zhu, Xuping
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA

Alpert, Nathaniel M.
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA

El Fakhri, Georges
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Dept Radiol, Ctr Adv Radiol Sci Nucl Med & Mol Imaging, Boston, MA 02114 USA