Cerebrospinal fluid monoamine metabolites in cocaine patients: no relationship to cue-induced craving

被引：2

作者：

Roy, A ^{[1
]}

Berman, J ^{[1
]}

Gonzalez, B ^{[1
]}

Roy, M ^{[1
]}

机构：

[1] New Jersey Healthcare Syst, Psychiat Serv 116A, Dept Vet Affairs, E Orange, NJ 07018 USA

来源：

JOURNAL OF PSYCHOPHARMACOLOGY | 2002年 / 16卷 / 03期

关键词：

cocaine; craving; dopamine; norepinephrine; serotonin;

D O I：

10.1177/026988110201600306

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We aimed to examine the relationship between central monoamine metabolites and craving cocaine in cocaine-dependent patients. Cerebrospinal fluid (CSF) monoamine metabolite concentrations were determined in 20 withdrawn cocaine-dependent patients. Patients also participated in a cue-elicited cocaine craving procedure. There were no significant relationships between cocaine craving scores and CSF concentrations of the dopamine metabolite, homovanillic acid, the serotonin metabolite, 5-hydroxyindoleacetic acid, or the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylglycol. CSF monoamine metabolite concentrations were not related to cocaine craving in withdrawn cocaine-dependent patients.

引用

页码：227 / 229

页数：3

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