Fleischner Society Visual Emphysema CT Patterns Help Predict Progression of Emphysema in Current and Former Smokers: Results from the COPDGene Study

被引：38

作者：

El Kaddouri, Bilal ^{[1
]}

Strand, Matthew J. ^{[2
]}

Baraghoshi, David ^{[2
]}

Humphries, Stephen M. ^{[3
]}

Charbonnier, Jean-Paul ^{[4
]}

van Rikxoort, Eva M. ^{[4
]}

Lynch, David A. ^{[3
]}

机构：

[1] Univ Libre Bruxelles, Hop Erasme, Dept Radiol, Route Lennik 808, B-1070 Brussels, Belgium

[2] Natl Jewish Hlth, Div Biostat & Bioinformat, Denver, CO USA

[3] Natl Jewish Hlth, Dept Radiol, Denver, CO USA

[4] Radboud Univ Nijmegen, Med Ctr, Dept Radiol & Nucl Med, Nijmegen, Netherlands

来源：

RADIOLOGY | 2021年 / 298卷 / 02期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; LUNG DENSITY; QUANTIFICATION; DENSITOMETRY; ASSOCIATION; STATEMENT; AIRWAYS;

D O I：

10.1148/radiol.2020200563

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background: The correlation between visual emphysema patterns and subsequent progression of disease may provide a way to enrich a study population for treatment trials of emphysema. Purpose: To evaluate the potential relationship between emphysema visual subtypes and progression of emphysema and gas trapping. Materials and Methods: Current and former smokers with and without chronic obstructive pulmonary disease (COPD) enrolled in the prospective Genetic Epidemiology of COPD (COPDGene) study (Clink-ffrials.gov identifier: NCF02445183) between 2008 and 2011 had their Fleischner Society visual CT scores assessed at baseline, quantitative inspiratory, and expiratory Cl` and at 5 years. They also underwent pulmonary function testing at baseline CT and at 5 years. The dependent variables were inspiratory lung density at 15th percentile (adjusted for lung, volume) as a measure of emphysema and percentage of lung volume with attenuation less than 856 HU at expiratory CT as a measure of air trapping, Statistical analysis used a linear mixed model, adjusted for age, height, sex, race, smoking status, and scanner make. Results: A total of 1166 participants (mean age, 60 years +/- 9 [standard deviation]; 2091 [50%] men) were evaluated. In participants with COPD (1655 participants, 10%), those with visual presence of mild, moderate, and confluent emphysema at baseline CT showed a mean decline in lung densiry of 4.6 g/L +/- 1.1 (P < .001), 6.7 g/L +/- 1.1 (P < .001), and 6.4 g/L +/- 1.2 (P < .001), respectively, compared with 2.4 g/L +/- 1.3 (P < .001) for those with trace emphysema. For participants without COPD, those with visual presence of mild and moderate emphysema at baseline CT showed a mean decline in lung density of 3.6 g/L +/- 1.0 (P < .001) and 3.1 g/L +/- 1.6 (P < .001), respectively, compared with 1.8 g/L +/- 1.0 (P < .001) for those with trace, emphysema. Conclusion: The pattern of parenchymal emphysema at baseline CT was an independent predictor of subsequent progression emphysema in participants who are current or filmier cigarette smokers with and without chronic obstructive pulmonary disease. (C) RSNA, 2020

引用

页码：441 / 449

页数：9

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