Salivary Biomarkers for the Detection of Malignant Tumors That are Remote from the Oral Cavity

被引：67

作者：

Bigler, Lenora R. ^{[1
]}

Streckfus, Charles F. ^{[1
]}

Dubinsky, William P. ^{[1
]}

机构：

[1] Univ Texas Houston, Dent Branch, Dept Diagnost Sci, Houston, TX 77030 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2009年 / 29卷 / 01期

关键词：

Saliva; Breast cancer; Mass spectrometry; Diagnosis; Biomarkers; Proteins; Cell signaling and pathways; BREAST-CANCER; PROTEIN EXPRESSION; MASS-SPECTROMETRY; DUCTAL CARCINOMA; IDENTIFICATION; MAMMARY; ALPHA; WOMEN; GENE; TIME;

D O I：

10.1016/j.cll.2009.01.004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Proteomic analyses by mass spectrometry are propelling the field of medical diagnostics forward at unprecedented rates because of its ability reliably to identify proteins that are at the femtomole level in concentration. These advancements have also benefited biomarker research to the point where saliva is now recognized as an excellent diagnostic medium for the detection of malignant tumors that are remote from the oral cavity. Saliva is easy to collect and may provide diagnostic information about a variety of cancers. In particular, proof-of-principle has been demonstrated for salivary biomarker research. This article reviews the literature, discusses the theories associated with saliva-based tumor diagnostics, and presents the current research focused on the use of saliva as a diagnostic medium for the detection of cancer.

引用

页码：71 / +

页数：17

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