Longitudinal MR Imaging of Iron in Multiple Sclerosis: An Imaging Marker of Disease

被引:61
作者
Walsh, Andrew J. [1 ]
Blevins, Gregg [2 ]
Lebel, R. Marc [1 ]
Seres, Peter [1 ]
Emery, Derek J. [3 ]
Wilman, Alan H. [1 ]
机构
[1] Univ Alberta, Fac Med & Dent, Dept Biomed Engn, Edmonton, AB T6G 2V2, Canada
[2] Univ Alberta, Fac Med & Dent, Div Neurol, Edmonton, AB T6G 2V2, Canada
[3] Univ Alberta, Fac Med & Dent, Dept Radiol & Diagnost Imaging, Edmonton, AB T6G 2V2, Canada
基金
加拿大健康研究院;
关键词
BRAIN IRON; GRAY-MATTER; MAGNETIC-FIELD; T2; DISABILITY; RELAXATION; IMAGES; HOMEOSTASIS; IMPAIRMENT; VALIDATION;
D O I
10.1148/radiol.13130474
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To investigate the relationship between magnetic resonance (MR) imaging markers of iron content and disease severity in patients with multiple sclerosis (MS) over a 2-year period. Materials and Methods: This prospective study was approved by the local ethics committee, and written informed consent was obtained from all participants. Seventeen patients with MS and 17 control subjects were examined twice, 2 years apart, by using phase imaging and transverse relaxation (R2*) mapping at 4.7 T. Quantitative differences in iron content in deep gray matter between patients and control subjects were evaluated with repeated-measures multivariate analysis of variance separately for R2* mapping and phase imaging. Multiple regression analysis was used to evaluate correlations of MR imaging measures, both 2-year-difference and single-time measurements, to baseline disease severity. Results: R2* mapping using 2-year-difference measurements had the highest correlation to disease severity (r = 0.905, P < .001) compared with R2* mapping using single-time measurements (r = 0.560, P =.019) and phase imaging by using either single-time (r = 0.539, P = .026) or 2-year-difference (r = 0.644, P = .005) measurements. Significant increases in R2* occur during 2 years in the substantia nigra (P < .001) and globus pallidus (P = .035), which are both predictors of disease in regression analysis, in patients compared with control subjects. There were group differences in the substantia nigra, globus pallidus, pulvinar thalamus, thalamus, and caudate nucleus, compared with control subjects with R2* mapping (P < .05), and group differences in the caudate nucleus and pulvinar thalamus, compared with control subjects with phase imaging (P < .05). Conclusion: There are significant changes in deep gray matter iron content in MS during 2 years measured with MR imaging, changes that are strongly related to physical disability. Longitudinal measurements may produce a higher correlation to disease severity compared with single-time measurements because baseline iron content of deep gray matter is variable among subjects. (C) RSNA, 2013
引用
收藏
页码:186 / 196
页数:11
相关论文
共 39 条
[1]   Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla [J].
Bagnato, Francesca ;
Hametner, Simon ;
Yao, Bing ;
van Gelderen, Peter ;
Merkle, Hellmut ;
Cantor, Fredric K. ;
Lassmann, Hans ;
Duyn, Jeff H. .
BRAIN, 2011, 134 :3599-3612
[2]   Brain iron homeostasis and neurodegenerative disease [J].
Benarroch, Eduardo E. .
NEUROLOGY, 2009, 72 (16) :1436-1440
[3]   Longitudinal gray matter changes in multiple sclerosisuDifferential scanner and overall disease-related effects [J].
Bendfeldt, Kerstin ;
Hofstetter, Louis ;
Kuster, Pascal ;
Traud, Stefan ;
Mueller-Lenke, Nicole ;
Naegelin, Yvonne ;
Kappos, Ludwig ;
Gass, Achim ;
Nichols, Thomas E. ;
Barkhof, Frederik ;
Vrenken, Hugo ;
Roosendaal, Stefan D. ;
Geurts, Jeroen J. G. ;
Radue, Ernst-Wilhelm ;
Borgwardt, Stefan J. .
HUMAN BRAIN MAPPING, 2012, 33 (05) :1225-1245
[4]   Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity [J].
Bermel, RA ;
Puli, SR ;
Rudick, RA ;
Weinstock-Guttman, B ;
Fisher, E ;
Munschauer, FE ;
Bakshi, R .
ARCHIVES OF NEUROLOGY, 2005, 62 (09) :1371-1376
[5]   Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis [J].
Brass, S. D. ;
Benedict, R. H. B. ;
Weinstock-Guttman, B. ;
Munschauer, F. ;
Bakshi, R. .
MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (04) :437-444
[6]   A longitudinal study of abnormalities on MRI and disability from multiple sclerosis [J].
Brex, PA ;
Ciccarelli, O ;
O'Riordan, JI ;
Sailer, M ;
Thompson, AJ ;
Miller, DH .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (03) :158-164
[7]   NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1 [J].
Cheah, Jaime H. ;
Kim, Sangwon F. ;
Hester, Lynda D. ;
Clancy, Kathleen W. ;
Patterson, Stanley E., III ;
Papadopoulos, Vassilios ;
Snyder, Solomon H. .
NEURON, 2006, 51 (04) :431-440
[8]   Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes [J].
Dalton, CM ;
Chard, DT ;
Davies, GR ;
Miszkiel, KA ;
Altmann, DR ;
Fernando, K ;
Plant, GT ;
Thompson, AJ ;
Miller, DH .
BRAIN, 2004, 127 :1101-1107
[9]   REDUCED SIGNAL INTENSITY ON MR IMAGES OF THALAMUS AND PUTAMEN IN MULTIPLE-SCLEROSIS - INCREASED IRON CONTENT [J].
DRAYER, B ;
BURGER, P ;
HURWITZ, B ;
DAWSON, D ;
CAIN, J .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1987, 149 (02) :357-363
[10]   Fast multislice mapping of the myelin water fraction using multicompartment analysis of T2* decay at 3T:: A preliminary postmortem study [J].
Du, Yiping P. ;
Chu, Renxin ;
Hwang, Dosik ;
Brown, Mark S. ;
Kleinschmidt-DeMasters, Bette K. ;
Singel, Debra ;
Simon, Jack H. .
MAGNETIC RESONANCE IN MEDICINE, 2007, 58 (05) :865-870