The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity

被引:40
作者
Cancro, M. P. [1 ]
机构
[1] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19104 USA
关键词
D O I
10.1136/ard.2006.058412
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The B lymphocyte stimulator (BLyS; also termed BAFF) family of ligands and receptors plays a central role in B lymphocyte development, selection, and homoeostasis. Members of this family can independently influence different B cell subsets, because the interactions between the two ligands and three receptors vary, and the receptors themselves are differentially expressed among developing, naive, and antigen experienced B cell subsets. These properties prompt careful assessment of how ablative therapies may influence the behaviour of upstream or downstream B lineage populations, as well as how the implementation and expectations of therapeutics targeting BLyS family members must be guided by knowledge of the B cell subsets contributing to pathogenesis.
引用
收藏
页码:34 / 36
页数:3
相关论文
共 38 条
[1]   Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation [J].
Allman, D ;
Lindsley, RC ;
DeMuth, W ;
Rudd, K ;
Shinton, SA ;
Hardy, RR .
JOURNAL OF IMMUNOLOGY, 2001, 167 (12) :6834-6840
[2]  
ALLMAN DM, 1992, J IMMUNOL, V149, P2533
[3]  
ALLMAN DM, 1993, J IMMUNOL, V151, P4431
[4]   The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation [J].
Cancro, MP .
IMMUNOLOGICAL REVIEWS, 2004, 202 :237-249
[5]   Peripheral B-cell maturation: the intersection of selection and homeostasis [J].
Cancro, MP .
IMMUNOLOGICAL REVIEWS, 2004, 197 :89-101
[6]   Homeostatic niche specification among naive and activated B cells: A growing role for the BLyS family of receptors and ligands [J].
Crowley, JE ;
Treml, LS ;
Stadanlick, JE ;
Carpenter, E ;
Cancro, MP .
SEMINARS IN IMMUNOLOGY, 2005, 17 (03) :193-199
[7]   Signaling thresholds and interclonal competition in preimmune B-cell selection [J].
Cyster, JG .
IMMUNOLOGICAL REVIEWS, 1997, 156 :87-101
[8]   COMPETITION FOR FOLLICULAR NICHES EXCLUDES SELF-REACTIVE CELLS FROM THE RECIRCULATING B-CELL REPERTOIRE [J].
CYSTER, JG ;
HARTLEY, SB ;
GOODNOW, CC .
NATURE, 1994, 371 (6496) :389-395
[9]   REDUCED LIFE-SPAN OF ANERGIC SELF-REACTIVE B-CELLS IN A DOUBLE-TRANSGENIC MODEL [J].
FULCHER, DA ;
BASTEN, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (01) :125-134
[10]   The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help [J].
Fulcher, DA ;
Lyons, AB ;
Korn, SL ;
Cook, MC ;
Koleda, C ;
Parish, C ;
Fazekas de St Groth, B ;
Basten, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) :2313-2328