Measurement of ibuprofen binding to mixed monolayers containing β-cyclodextrin active sites

被引：17
作者：
Chmurski, K [1 ]
Temeriusz, A [1 ]
Bilewicz, R [1 ]
机构：
[1] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2004年 / 49卷 / 1-2期
关键词：
gold surface; ibuprofen; self-assembly; voltammetry;
D O I：
10.1023/B:JIPH.0000031134.27231.e5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A molecular imprinting method involving a three-step sequential self-assembly procedure was applied to prepare gold electrodes responsive towards ibuprofen. The electrode modified with the cyclodextrin derivative binds ferrocene to form an electroactive complex with the ferrocene oxidation current decreasing in the presence of ibuprofen in the solution. The competition of ferrocene and ibuprofen for the cyclodextrin cavities in the monolayer provided a means for the determination of the binding constants of ibuprofen with two derivatives of lipoylamide beta-cyclodextrin of different hydrophobicity.
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收藏
页码：187 / 191
页数：5
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