Derivation of germ cells from embryonic stem cells

被引：0
作者：
Kehler, J. [1 ]
Huebner, K. [1 ]
Schoeler, H. R. [1 ]
机构：
[1] Univ Penn, Sch Vet Med, Ctr Anim Transgenesis & Germ Cell Res, Germline Dev Grp, 382 W St Rd, Kennett Sq, PA 19348 USA
来源：
STEM CELLS IN REPRODUCTION AND IN THE BRAIN | 2006年 / 60卷
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Embryonic stem cells (ESCs), derivatives of cells of early mammalian embryos, have proven to be one of the most powerful tools in developmental and stem cell biology. When injected into embryos, ESCs can contribute to tissues derived from all three germ layers and to the germline. Prior studies have successfully shown that ESCs can recapitulate features of embryonic development by spontaneously forming somatic lineages in culture. Amazingly, recently it has been shown that mouse ESCs can also give rise to primordial germ cells (PGCs) in culture that are capable of undergoing meiosis and forming both male and female gametes. While the full potential of these ES-derived germ cells and gametes remains to be demonstrated, these discoveries provide a new approach for studying reproductive biology and medicine.
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页码：125 / +
页数：8
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