Monoclonal Antibodies in Cancer Therapy: Mechanisms, Successes and Limitations

被引:47
作者
Coulson, A. [1 ]
Levy, A. [1 ]
Gossell-Williams, M. [1 ]
机构
[1] Univ W Indies, Dept Basic Med Sci, Pharmacol Sect, Kingston 7, Jamaica
关键词
Antigenic targets; cancer therapy; clinical benefits; monoclonal antibodies; CHRONIC LYMPHOCYTIC-LEUKEMIA; BRENTUXIMAB VEDOTIN; COLORECTAL-CANCER; LYMPHOMA; RITUXIMAB; CHEMOTHERAPY; RADIOIMMUNOTHERAPY; TRASTUZUMAB; BEVACIZUMAB; INDUCTION;
D O I
10.7727/wimj.2013.241
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Rituximab was the first chemotherapeutic monoclonal antibody (CmAb) approved for clinical use in cancer therapeutics in 1997 and has significantly improved the clinical outcomes in non-Hodgkin's lymphoma. Since then, numerous CmAbs have been developed and approved for the treatment of various haematologic and solid human cancers. In this review, the classification, efficacy and significantly reduced toxicity of CmAbs available for use in the United States of America are presented. Finally, the limitations of CmAbs and future considerations are explored.
引用
收藏
页码:650 / 654
页数:5
相关论文
共 50 条
  • [31] The potential of monoclonal antibodies for colorectal cancer therapy
    Fatemeh Heidari
    Soheil Madadi
    Neda Alizadeh
    Mohammad Hossein Alimardani
    Armin Safari
    Mohammad Hossein Armand
    Elahe Pishgahzadeh
    Meysam Soleimani
    Medical Oncology, 40
  • [32] Monoclonal antibodies in targeted therapy
    Powroznik, Beata
    Kubowicz, Paulina
    Pekala, Elzbieta
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2012, 66 : 663 - 673
  • [33] Monoclonal antibodies in the treatment of advanced colorectal cancer
    Capdevila, J.
    Saura, C.
    Macarulla, T.
    Casado, E.
    Ramos, F. J.
    Tabernero, J.
    EJSO, 2007, 33 : S24 - S34
  • [34] The safety of monoclonal antibodies for treatment of colorectal cancer
    Berger, Martin D.
    Lenz, Heinz-Josef
    EXPERT OPINION ON DRUG SAFETY, 2016, 15 (06) : 799 - 808
  • [35] Combinatorial treatments including vaccines, chemotherapy and monoclonal antibodies for cancer therapy
    Baxevanis, Constantin N.
    Perez, Sonia A.
    Papamichail, Michael
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (03) : 317 - 324
  • [36] Combinatorial treatments including vaccines, chemotherapy and monoclonal antibodies for cancer therapy
    Constantin N. Baxevanis
    Sonia A. Perez
    Michael Papamichail
    Cancer Immunology, Immunotherapy, 2009, 58 : 317 - 324
  • [37] Monoclonal Antibodies for the Treatment of Cancer
    Pento, Joseph Thomas
    ANTICANCER RESEARCH, 2017, 37 (11) : 5935 - 5939
  • [38] Recent progress in cancer therapy with radiolabeled monoclonal antibodies
    Goldenberg, David M.
    Sharkey, Robert M.
    THERAPEUTIC DELIVERY, 2011, 2 (06) : 675 - 679
  • [39] Use of monoclonal antibodies in cancer immunotherapy: types and mechanisms of action
    Damian-Blanco, Paola
    Ahuexoteco-Sanchez, Selene
    Carbajal-Gallardo, Adrian A.
    Coctecon-Chavelas, Fredi C.
    Rodriguez-Nava, Cynthia
    Vences-Velazquez, Amalia
    Medina-Flores, Yolanda
    Mata-Ruiz, Olga
    Lloret-Sanchez, Lourdes
    Cortes-Sarabia, Karen
    BOLETIN MEDICO DEL HOSPITAL INFANTIL DE MEXICO, 2023, 80 (03): : 153 - 164
  • [40] The developing trend of monoclonal antibodies in the treatment of colorectal cancer
    Elfiky, Aymen A.
    Saif, Muhammad W.
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2007, 7 (06) : 871 - 883