Monoclonal Antibodies in Cancer Therapy: Mechanisms, Successes and Limitations

被引：46
作者：
Coulson, A. [1 ]
Levy, A. [1 ]
Gossell-Williams, M. [1 ]
机构：
[1] Univ W Indies, Dept Basic Med Sci, Pharmacol Sect, Kingston 7, Jamaica
来源：
WEST INDIAN MEDICAL JOURNAL | 2014年 / 63卷 / 06期
关键词：
Antigenic targets; cancer therapy; clinical benefits; monoclonal antibodies; CHRONIC LYMPHOCYTIC-LEUKEMIA; BRENTUXIMAB VEDOTIN; COLORECTAL-CANCER; LYMPHOMA; RITUXIMAB; CHEMOTHERAPY; RADIOIMMUNOTHERAPY; TRASTUZUMAB; BEVACIZUMAB; INDUCTION;
D O I：
10.7727/wimj.2013.241
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rituximab was the first chemotherapeutic monoclonal antibody (CmAb) approved for clinical use in cancer therapeutics in 1997 and has significantly improved the clinical outcomes in non-Hodgkin's lymphoma. Since then, numerous CmAbs have been developed and approved for the treatment of various haematologic and solid human cancers. In this review, the classification, efficacy and significantly reduced toxicity of CmAbs available for use in the United States of America are presented. Finally, the limitations of CmAbs and future considerations are explored.
引用
收藏
页码：650 / 654
页数：5
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