Cascade Michael-Intramolecular Transesterification-Elimination Reaction of 3,4-Dihydro-3-nitrochromen-2-ones and β,γ-Unsaturated α-Oxo Esters: An Efficient Access to 2-Pyrone Derivatives

被引：11

作者：

Zhang, Li ^{[1
]}

Wang, Youming ^{[1
]}

Song, Haibin ^{[1
]}

Zhou, Zhenghong ^{[1
]}

Tang, Chuchi ^{[1
]}

机构：

[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 15期

基金：

中国国家自然科学基金;

关键词：

Synthetic methods; Domino reactions; Oxygen heterocycles; Michael addition; Transesterification; Elimination; DIELS-ALDER REACTION; ONE-POT SYNTHESIS; CATALYZED SYNTHESIS; CYCLIZATION REACTION; DEFENSIVE STEROIDS; CYCLOADDITION; PYRONES; KETONES; ACIDS; 3,5-DIBROMO-2-PYRONE;

D O I：

10.1002/ejoc.201301876

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multisubstituted 2-oxopyran-6-carboxylic acid derivatives were synthesized under mild reaction conditions through a base-promoted reaction between 3,4-dihydro-3-nitrochromen-2-ones and ,-unsaturated -oxo esters to give products in excellent yields. The reaction is believed to proceed through a cascade Michael-intramolecular transesterification-elimination process.

引用

页码：3163 / 3169

页数：7

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