The molecular basis of endothelial cell plasticity

被引：335

作者：

Dejana, Elisabetta ^{[1
,2
]}

Hirschi, Karen K. ^{[3
,4
,5
]}

Simons, Michael ^{[6
,7
]}

机构：

[1] FIRC Inst Mol Oncol, Vasc Biol Unit, I-20129 Milan, Italy

[2] Uppsala Univ, Dept Immunol Genet & Pathol, S-75185 Uppsala, Sweden

[3] Yale Cardiovasc Res Ctr, Dept Internal Med, New Haven, CT 06511 USA

[4] Yale Cardiovasc Res Ctr, Dept Genet, New Haven, CT 06511 USA

[5] Yale Cardiovasc Res Ctr, Dept Biomed Engn, New Haven, CT 06511 USA

[6] Yale Univ, Sch Med, Yale Cardiovasc Res Ctr, Dept Internal Med, 333 Cedar St, New Haven, CT 06511 USA

[7] Yale Univ, Sch Med, Dept Cell Biol, 333 Cedar St, New Haven, CT 06511 USA

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

基金：

欧洲研究理事会;

关键词：

TO-MESENCHYMAL TRANSITION; CEREBRAL CAVERNOUS MALFORMATION; REGULATES HEMATOPOIETIC STEM; FLUID SHEAR-STRESS; PERMEABILITY IN-VIVO; VE-CADHERIN; DEFINITIVE HEMATOPOIESIS; HAEMOGENIC ENDOTHELIUM; HEMOGENIC ENDOTHELIUM; VASCULAR-DISEASE;

D O I：

10.1038/ncomms14361

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also undergo hematopoietic transition giving rise to multi-lineage hematopoietic stem and progenitors while others acquire mesenchymal properties necessary for heart development. In the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input. The failure to do so leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases. A better understanding of these phenotypic changes may lead to development of new therapeutic interventions.

引用

页数：11

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