DOT1L-HES6 fusion drives androgen independent growth in prostate cancer

被引：17

作者：

Annala, Matti ^{[1
,2
]}

Kivinummi, Kati ^{[1
]}

Leinonen, Katri ^{[1
]}

Tuominen, Joonas ^{[1
]}

Zhang, Wei ^{[3
]}

Visakorpi, Tapio ^{[1
]}

Nykter, Matti ^{[1
]}

机构：

[1] Inst Biosci & Med Technol, Tampere, Finland

[2] Tampere Univ Technol, Dept Signal Proc, FIN-33101 Tampere, Finland

[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

EMBO MOLECULAR MEDICINE | 2014年 / 6卷 / 09期

关键词：

RECEPTOR GENE; TARGETS; ASCL1;

D O I：

10.15252/emmm.201404210

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

[No abstract available]

引用

页码：1121 / 1123

页数：3

共 8 条

[1] Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade [J].

Arora, Vivek K. ;

Schenkein, Emily ;

Murali, Rajmohan ;

Subudhi, Sumit K. ;

Wongvipat, John ;

Balbas, Minna D. ;

Shah, Neel ;

Cai, Ling ;

Efstathiou, Eleni ;

Logothetis, Chris ;

Zheng, Deyou ;

Sawyers, Charles L. .

CELL, 2013, 155 (06) :1309-1322

[2] Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets [J].

Beltran, Himisha ;

Rickman, David S. ;

Park, Kyung ;

Chae, Sung Suk ;

Sboner, Andrea ;

MacDonald, Theresa Y. ;

Wang, Yuwei ;

Sheikh, Karen L. ;

Terry, Stephane ;

Tagawa, Scott T. ;

Dhir, Rajiv ;

Nelson, Joel B. ;

de la Taille, Alexandre ;

Allory, Yves ;

Gerstein, Mark B. ;

Perner, Sven ;

Pienta, Kenneth J. ;

Chinnaiyan, Arul M. ;

Wang, Yuzhuo ;

Collins, Colin C. ;

Gleave, Martin E. ;

Demichelis, Francesca ;

Nanus, David M. ;

Rubin, Mark A. .

CANCER DISCOVERY, 2011, 1 (06) :487-495

[3] ChimeraScan: a tool for identifying chimeric transcription in sequencing data [J].

Iyer, Matthew K. ;

Chinnaiyan, Arul M. ;

Maher, Christopher A. .

BIOINFORMATICS, 2011, 27 (20) :2903-2904

[4] Acheate-scute like 1 (Ascl1) Is Required for Normal Delta-like (Dll) Gene Expression and Notch Signaling During Retinal Development [J].

Nelson, Branden R. ;

Hartman, Byron H. ;

Ray, Catherine A. ;

Hayashi, Toshinori ;

Bermingham-McDonogh, Olivia ;

Reh, Thomas A. .

DEVELOPMENTAL DYNAMICS, 2009, 238 (09) :2163-2178

[5] HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network [J].

Ramos-Montoya, Antonio ;

Lamb, Alastair D. ;

Russell, Roslin ;

Carroll, Thomas ;

Jurmeister, Sarah ;

Galeano-Dalmau, Nuria ;

Massie, Charlie E. ;

Boren, Joan ;

Bon, Helene ;

Theodorou, Vasiliki ;

Vias, Maria ;

Shaw, Greg L. ;

Sharma, Naomi L. ;

Ross-Adams, Helen ;

Scott, Helen E. ;

Vowler, Sarah L. ;

Howat, William J. ;

Warren, Anne Y. ;

Wooster, Richard F. ;

Mills, Ian G. ;

Neal, David E. .

EMBO MOLECULAR MEDICINE, 2014, 6 (05) :651-661

[6] MUTATION OF THE ANDROGEN-RECEPTOR GENE IN METASTATIC ANDROGEN-INDEPENDENT PROSTATE-CANCER [J].

TAPLIN, ME ;

BUBLEY, GJ ;

SHUSTER, TD ;

FRANTZ, ME ;

SPOONER, AE ;

OGATA, GK ;

KEER, HN ;

BALK, SP .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (21) :1393-1398

[7] IN-VIVO AMPLIFICATION OF THE ANDROGEN RECEPTOR GENE AND PROGRESSION OF HUMAN PROSTATE-CANCER [J].

VISAKORPI, T ;

HYYTINEN, E ;

KOIVISTO, P ;

TANNER, M ;

KEINANEN, R ;

PALMBERG, C ;

PALOTIE, A ;

TAMMELA, T ;

ISOLA, J ;

KALLIONIEMI, OP .

NATURE GENETICS, 1995, 9 (04) :401-406

[8] FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis [J].

Webb, Ashley E. ;

Pollina, Elizabeth A. ;

Vierbuchen, Thomas ;

Urban, Noelia ;

Ucar, Duygu ;

Leeman, Dena S. ;

Martynoga, Ben ;

Sewak, Madhavi ;

Rando, Thomas A. ;

Guillemot, Francois ;

Wernig, Marius ;

Brunet, Anne .

CELL REPORTS, 2013, 4 (03) :477-491

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