The role of mTOR in depression and antidepressant responses

被引：160
作者：
Abelaira, Helena M. [1 ]
Reus, Gislaine Z. [1 ,2 ]
Neotti, Morgana V. [1 ]
Quevedo, Joao [1 ,2 ]
机构：
[1] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Lab Neurociencias, BR-88806000 Criciuma, SC, Brazil
[2] Univ Texas Med Sch Houston, Dept Psychiat & Behav Sci, Ctr Expt Models Psychiat, Houston, TX USA
来源：
LIFE SCIENCES | 2014年 / 101卷 / 1-2期
关键词：
mTOR; Antidepressants; Ketamine; Depression; MAMMALIAN TARGET; SIGNALING PATHWAYS; KETAMINE TREATMENT; RAPAMYCIN; PHOSPHORYLATION; RECEPTOR; GROWTH; RAPTOR; DEXTROMETHORPHAN; TRANSLATION;
D O I：
10.1016/j.lfs.2014.02.014
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The aim of this study was to characterize the mTOR signaling cascade in depression and the actions that antidepressant drugs have on this pathway. Herein, a literature review was performed by verification and comparison of textbooks and journal articles that describe the characterization of the mTOR signaling cascade and its relationship to depression and antidepressant drugs, especially ketamine. Postmortem studies have shown robust deficits in the mammalian target of rapamycin (mTOR) signaling in the prefrontal cortex of subjects diagnosed with major depressive disorder. However, besides the mTOR signaling pathway having an antidepressant response to various drugs, this seems to be more associated with antidepressant N-methyl-D-aspartate (NMDA) receptor antagonists, such as ketamine. The characterization of the mTOR signaling pathway in depression and its action in response to antidepressants show great potential for the identification of new therapeutic targets for the development of antidepressant drugs. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：10 / 14
页数：5
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