Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?

被引：62

作者：

Reynard, Louise N. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Musculoskeletal Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2017年 / 62卷

关键词：

Osteoarthritis; Cartilage; Genetics; Epigenetics; DNA methylation; SUSCEPTIBILITY LOCUS; EPIGENETIC REGULATION; KNEE OSTEOARTHRITIS; EXPRESSION ANALYSIS; CPG SITES; INCREASES SUSCEPTIBILITY; ARTICULAR CHONDROCYTES; ALLELIC EXPRESSION; WIDE ASSOCIATION; COMMON VARIANTS;

D O I：

10.1016/j.semcdb.2016.04.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is complex and highly heritable, with genetic variation estimated to contribute to 50% of OA occurrence. Epigenetic alterations, including DNA methylation changes, have also been implicated in OA pathophysiology. This review examines what genetic and DNA methylation studies have taught us about the genes and pathways involved in OA pathology. The influence of DNA methylation on the molecular mechanisms underlying OA genetic risk and the consequence of this interaction on disease susceptibility and penetrance are also discussed. (C) 2016 The Author. Published by Elsevier Ltd.

引用

页码：57 / 66

页数：10

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