A "light-up" and "spectrum-shift" response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging

被引：43
作者：
Li, Jingjing [1 ,2 ]
You, Jia [2 ]
Zhuang, Yinping [2 ]
Han, Cuiping [1 ,2 ]
Hu, Junfeng [2 ]
Wang, Aming [2 ]
Xu, Kai [1 ,2 ]
Zhu, Jun-Jie [3 ]
机构：
[1] Xuzhou Med Coll, Affiliated Hosp, Dept Radiol, Xuzhou 221006, Peoples R China
[2] Xuzhou Med Coll, Sch Med Imaging, Xuzhou 221004, Peoples R China
[3] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 54期
基金：
中国国家自然科学基金;
关键词：
SIRNA DELIVERY; DNA; PROBES; EXPRESSION; MICRORNA; FLARES; CELLS;
D O I：
10.1039/c4cc00160e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have designed a novel multifunctional DNA scaffold for the synthesis of fluorescent silver nanoclusters (Ag NCs) using a one-pot approach. The obtained DNA/Ag NCs presented a "light-up" and "spectrum-shift" response to target DNA in vitro and could further image the tumor-related mRNA in living cells.
引用
收藏
页码：7107 / 7110
页数：4
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