The Immunology of Bipolar Disorder

被引：108
作者：
Barbosa, Izabela Guimaraes [1 ]
Machado-Vieira, Rodrigo [3 ,4 ]
Soares, Jair C. [5 ]
Teixeira, Antonio L. [1 ,2 ]
机构：
[1] Univ Fed Minas Gerais, Lab Interdisciplinar Invest Med, Fac Med, BR-30130100 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, IEAT, BR-30130100 Belo Horizonte, MG, Brazil
[3] Univ Sao Paulo, Inst & Dept Psiquiatria, Lab Neurociencias, LIM27, Sao Paulo, Brazil
[4] NIMH, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD 20892 USA
[5] UTHlth Med Sch, Dept Psychiat & Behav Sci, Houston, TX USA
来源：
NEUROIMMUNOMODULATION | 2014年 / 21卷 / 2-3期
关键词：
Mania; Depression; Aspirin; Interleukin; Lymphocytes; Mood disorder; AUTOIMMUNE-THYROIDITIS; LITHIUM TREATMENT; OXIDATIVE STRESS; MOOD DISORDERS; IMMUNE-SYSTEM; ACUTE MANIA; T-CELLS; CYTOKINES; SCHIZOPHRENIA; INFLAMMATION;
D O I：
10.1159/000356539
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bipolar disorder (BD) is a psychiatric condition associated with elevated frequency of clinical comorbidities and cognitive impairment. The neurobiology of BD is not completely understood. Recent evidence has implicated immune dysfunction in its physiopathology. Here, we review several data supporting the presence of immunological dysfunction in BD: (i) increased frequency of autoimmune diseases; (ii) distinct immune cell profile; (iii) release of/altered cytokines by stimulated mononuclear cells; (iv) elevated levels of circulating immune markers, and (v) inflammatory changes in the central nervous system. We also discuss the interplay between immunological dysfunction and neuroprogression in BD. (C) 2014 S. Karger AG, Basel
引用
收藏
页码：117 / 122
页数：6
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