Intestinal smooth muscle is required for patterning the enteric nervous system

被引：25

作者：

Graham, Hannah K. ^{[1
]}

Maina, Ivy ^{[1
]}

Goldstein, Allan M. ^{[1
]}

Nagy, Nandor ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Harvard Med Sch, Dept Pediat Surg, 185 Cambridge St,CPZN 6215, Boston, MA 02114 USA

[2] Semmelweis Univ, Dept Anat Histol & Embryol, Budapest, Hungary

来源：

JOURNAL OF ANATOMY | 2017年 / 230卷 / 04期

关键词：

NEURAL CREST CELLS; GASTROINTESTINAL-TRACT; EMBRYONIC-DEVELOPMENT; DIFFERENTIATION; GUT; PROLIFERATION; EXPRESSION; MIGRATION; NEURONS; GROWTH;

D O I：

10.1111/joa.12583

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The development of the enteric nervous system (ENS) and intestinal smooth muscle occurs in a spatially and temporally correlated manner, but how they influence each other is unknown. In the developing mid-gut of the chick embryo, we find that α-smooth muscle actin expression, indicating early muscle differentiation, occurs after the arrival of migrating enteric neural crest-derived cells (ENCCs). In contrast, hindgut smooth muscle develops prior to ENCC arrival. Smooth muscle development is normal in experimentally aganglionic hindguts, suggesting that proper development and patterning of the muscle layers does not rely on the ENS. However, inhibiting early smooth muscle development severely disrupts ENS patterning without affecting ENCC proliferation or apoptosis. Our results demonstrate that early intestinal smooth muscle differentiation is required for patterning the developing ENS. © 2017 Anatomical Society

引用

页码：567 / 574

页数：8

共 34 条

[31] THE ORIGIN OF INTRINSIC GANGLIA OF TRUNK VISCERA FROM VAGAL NEURAL CREST IN THE CHICK EMBRYO [J].