Cycloadditions in the Total Synthesis of Sporolide B

被引：21

作者：

Li, Pengfei ^{[1
]}

Menche, Dirk ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Organ Chem, D-69120 Heidelberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 28期

关键词：

biomimetic synthesis; cycloaddition; natural products; selectivity; total synthesis; ACTINOMYCETE SALINISPORA-TROPICA; CATALYZED 2+2+2 CYCLOADDITION; ALKYNE CYCLOTRIMERIZATION; CONSTRUCTION; 1,6-DIYNES; COMPLEXES;

D O I：

10.1002/anie.200901894

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Closing rings: A recent total synthesis of sporolide B by the Nicolaou group is highlighted by two advantageous cycloadditions. Firstly, a regioselective [2+2+2] cycloaddition of highly elaborate substrates assembles the halogenated aromatic ring and subsequently an orthoquinone [4+2] cyclization closes stereoselectively the dioxane-containing macrocycle. These approaches should be considered in complex target syntheses. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5078 / 5080

页数：3

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