Antibiotic treatment of acute bacterial skin and skin structure infections

被引:10
作者
Russo, Alessandro [1 ]
Vena, Antonio [2 ,3 ]
Bassetti, Matteo [2 ,3 ,4 ]
机构
[1] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Infect & Trop Dis Unit, Genoa, Italy
[2] Univ Genoa, Dept Hlth Sci DISSAL, Genoa, Italy
[3] Osped Policlin San Martino, IRCCS, Infect Dis Unit, Genoa, Italy
[4] Osped Policlin San Martino IRCCS, Infect Dis Unit, Lgo R Benzi 10, I-16132 Genoa, Italy
关键词
acute bacterial skin and skin structure infections; antibiotic therapy; multidrug-resistant pathogens; new antibiotics; source control of infection; SOFT-TISSUE INFECTIONS; RESISTANT STAPHYLOCOCCUS-AUREUS; COMPLICATED SKIN; ACINETOBACTER-BAUMANNII; ANTIMICROBIAL THERAPY; HOSPITALIZED-PATIENTS; TREATMENT FAILURE; CLINICAL-TRIAL; MANAGEMENT; MULTICENTER;
D O I
10.1097/QCO.0000000000000822
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Purpose of reviewAcute bacterial skin and skin structure infections (ABSSSI) are a leading cause of morbidity, with a considerable variety of clinical presentation and a wide range of etiological pathogens. Of importance, the spread of multidrug-resistant (MDR) strains (i.e. methicillin-resistant Staphylococcus aureus or Gram-negative bacteria) is increasingly reported in some regions. in this review, we summarize the current clinical approach to patients with ABSSSI.Recent findingsAccurate diagnosis and identification of risk factors for MDR pathogens are key determinants for administering appropriate therapy in patients with ABSSSI. In daily clinical practice, this can be critical as there are many features defining the 'high risk patient' including both disease and host-associated risk factors.Antibiotic therapy should be based according to the different clinical spectrum of disease belonging to the ABSSSI, on the pathogens most likely to be involved and local resistance. Careful evaluation of antibiotic therapy after 48-72 h of initial therapy could help clinicians to early identify patients with treatment failure and to consider an alternative approach. Close monitoring of patients with multiple comorbidities, drug-drug interaction or adverse host factors are also necessary.
引用
收藏
页码:120 / 127
页数:8
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