Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance

被引：6

作者：

Ramadhani, Habib O. ^{[1
,2
]}

Muiruri, Charles ^{[3
]}

Maro, Venance P. ^{[1
,4
]}

Nyombi, Balthazar ^{[1
,2
]}

Omondi, Michael ^{[3
]}

Mushi, Julian B. ^{[5
]}

Lirhunde, Eileen S. ^{[6
]}

Bartlett, John A. ^{[3
,7
]}

机构：

[1] KCMC, POB 3010, Moshi, Tanzania

[2] Kilimanjaro Christian Med Univ Coll, Moshi, Tanzania

[3] Duke Global Hlth Inst, Durham, NC USA

[4] Mawenzi Reg Hosp, Moshi, Tanzania

[5] Kilema Designated Dist Hosp, Moshi, Tanzania

[6] Kibosho Designated Dist Hosp, Moshi, Tanzania

[7] Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA

来源：

AIDS AND BEHAVIOR | 2018年 / 22卷 / 05期

基金：

美国国家卫生研究院;

关键词：

HIV; Repackaging of anti-retro-viral; Virological suppression; Stigma; ART resistance mutations; VIROLOGICAL FAILURE; NATURAL-HISTORY; HIV; ADHERENCE; STIGMA; STRATEGIES; INFECTION; HIV/AIDS; TANZANIA; SUBTYPE;

D O I：

10.1007/s10461-017-1721-x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Patient-initiated repackaging of antiretroviral therapy (ART) refers to removal of ART medications from their original manufacturer's containers, and putting them into alternative containers. This behavior may be triggered by stigma associated with HIV infection, and may impact patient outcomes. We assessed association between patient initiated repackaging of ART and failure to achieve viral suppression (FVS) in a sample of 450 HIV-infected adults (8 years) on first line ART for 6 months. FVS was defined as a plasma HIV RNA level 400 copies/mL. A total of 197 (43.7%) patients reported repackaging their ART medications. One hundred ninety-one patients (42.4%) failed to suppress and FVS was associated with medication repackaging [adjusted odds ratio (aOR), 2.2; 95% CI 1.4-3.3.] Adherence to ART was also associated with FVS (aOR; 0.4; 95% CI 0.2-0.6.). Benefits of retaining drugs in their original packaging along with adherence to ART should be emphasized to reduce the risk of FVS.

引用

页码：1671 / 1678

页数：8

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