Synthesis of thermo-sensitive polyelectrolyte complex nanoparticles from CS-g-PNIPAM and SA-g-PNIPAM for controlled drug release

被引：34

作者：

Qi, Minyi ^{[1
]}

Li, Guiying ^{[1
]}

Yu, Nana ^{[1
]}

Meng, Yanfeng ^{[1
]}

Liu, Xunyong ^{[1
]}

机构：

[1] Ludong Univ, Coll Chem & Mat Sci, Yantai 264025, Peoples R China

来源：

MACROMOLECULAR RESEARCH | 2014年 / 22卷 / 09期

基金：

中国国家自然科学基金;

关键词：

controlled release; 5-fluorouracil; nanoparticles; polyelectrolyte; thermo-sensitivity; CHITOSAN; DELIVERY; PH; 5-FLUOROURACIL; COPOLYMERS;

D O I：

10.1007/s13233-014-2134-6

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this paper, thermo-sensitive polyelectrolyte complex nanoparticles assembled from chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAM) and sodium alginate-graft-poly(N-isopropylacrylamide) (SA-g-PNIPAM) were prepared for entrapment and release of 5-fluorouracil (5-FU). The morphology and size of the nanoparticles were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The polyelectrolyte complex nanoparticles showed a narrow size distribution. The hydrogen bonding interactions between nanoparticles and 5-FU, which was determined by fourier-transformed infrared spectroscopy (FTIR), increased drug loading. Glutaraldehyde, as a cross-linking agent, reinforced the nanoparticle structure and decreased the burst drug release. When changing temperature, pH, or ionic strength, a sustained and controlled drug release was observed. The novel complex nanoparticles with environmentally sensitive properties are expected to be useful in the field of intelligent drug delivery system.

引用

页码：1004 / 1011

页数：8