Humoral immune responses to microbial infections in the genital tract

被引：94
|
作者：
Russell, MW
Mestecky, J
机构：
[1] SUNY Buffalo, Dept Microbiol, Buffalo, NY 14214 USA
[2] SUNY Buffalo, Dept Oral Biol, Buffalo, NY 14214 USA
[3] SUNY Buffalo, Witebsky Ctr Mictobial Pathogenesis & Immunol, Buffalo, NY 14214 USA
[4] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA
[5] Univ Alabama, Dept Med, Birmingham, AL 35294 USA
来源：
MICROBES AND INFECTION | 2002年 / 4卷 / 06期
关键词：
mucosal immunity; reproductive tract; immunoglobulins; secretory IgA; IgG; antibodies; immune response; vaccines; immunization; sexually transmitted diseases;
D O I：
10.1016/S1286-4579(02)01585-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human reproductive tracts represent components of the mucosal immune system with unique features. Although secretory IgA is present, IgG is more abundant, and typical mucosa-associated lymphoid tissue for generating common mucosal immune responses is absent. Antibody responses to genital infections or to locally applied vaccines are usually modest, but alternative strategies for eliciting genital tract antibodies are being developed. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：667 / 677
页数：11
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