Mononuclear CuII-Phenolate Bioinspired Complex is Catalytically Promiscuous: Phosphodiester and Peptide Amide Bond Cleavage

被引：28

作者：

Bof Oliveira, Mauricio C. ^{[2
]}

Mazera, Deise ^{[2
]}

Scarpellini, Marciela ^{[1
]}

Severino, Patricia Cardoso ^{[2
]}

Neves, Ademir ^{[1
]}

Terenzi, Hernan ^{[2
]}

机构：

[1] Univ Fed Santa Catarina, Dept Quim, Lab Bioinorgan & Cristalog, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Bioquim, Ctr Biol Mol Estrutural, BR-88040900 Florianopolis, SC, Brazil

来源：

INORGANIC CHEMISTRY | 2009年 / 48卷 / 07期

关键词：

HYDROLYTIC DNA CLEAVAGE; PHOSPHATE DIESTER HYDROLYSIS; PURPLE ACID-PHOSPHATASES; BINUCLEAR METALLOHYDROLASES; RATE ENHANCEMENT; COPPER(II); DINUCLEAR; ENZYME; BIOCATALYSIS; RELEVANCE;

D O I：

10.1021/ic802208v

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In this work, the cleavage activity of the metal complex [Cu(C21H21N3O2)(OH2)(2)](2+) is demonstrated to occur toward double-stranded DNA, in addition to its previously described amide bond cleavage activity, thus suggesting catalytic promiscuity for this complex.

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收藏

页码：2711 / 2713

页数：3

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