Vanishing White Matter Hyperintensities in CADASIL: A Case Report with Insight into Disease Mechanisms

被引：5
作者：
Jouvent, Eric [1 ,2 ,3 ,4 ,5 ]
Alili, Nassira [2 ,3 ,4 ]
Herve, Dominique [2 ,3 ,4 ]
Chabriat, Hugues [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Paris, Paris, France
[2] Lariboisiere Hosp, AP HP, Dept Neurol, Paris, France
[3] Lariboisiere Hosp, AP HP, Referral Ctr Rare Vasc Dis Brain & Retina CERVCO, Paris, France
[4] Univ Paris, FHU NeuroVasc, Paris, France
[5] U1141 INSERM, Paris, France
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 78卷 / 03期
关键词：
Brain volume; CADASIL; valpromide; white matter hyperintensities; BRAIN; ACCURATE; ROBUST;
D O I：
10.3233/JAD-201086
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In a woman with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) followed for 15 years, we observed magnetic resonance imaging white matter hyperintensities that vanished in the anterior temporal poles while the brain volume decreased unexpectedly. These imaging changes were transient and detected when the patient was being treated by valproic acid for stabilizing mood disturbances. This intriguing case supports that mechanisms underlying white matter hyperintensities can vary from one brain area to another and that important modifications of water influx into the brain tissue might be involved in some imaging features of CADASIL.
引用
收藏
页码：907 / 910
页数：4
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