Synthesis and biological activity of arylaliphatic N-(2-aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides

被引：1

作者：

Hoang, D. Q. ^{[1
]}

Borisova, E. Ya. ^{[1
]}

Borisova, N. Yu. ^{[1
]}

Asilova, N. Yu. ^{[1
]}

Kaldyrkaeva, O. S. ^{[2
]}

Arzamastsev, E. V. ^{[2
]}

Terekhova, O. A. ^{[2
]}

Afanas'eva, E. Yu. ^{[2
]}

Levitskaya, E. L. ^{[2
]}

机构：

[1] Moscow Technol Univ, Inst Fine Chem Technol, 86 Prosp Vernadskogo, Moscow 119571, Russia

[2] Russian Cardiol Res & Prod Complex, 15a Ul 3 Ya Cherepkovskaya, Moscow 121552, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2018年 / 67卷 / 01期

关键词：

styrene oxide; ethylenediamine; diamino alcohols; amino amides; acylation; arrhythmia; biological activity; AGENTS;

D O I：

10.1007/s11172-018-2048-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-(2-Aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides were synthesized from styrene oxide by ring opening with N,N-disubstituted ethylenediamines followed by N-acylation. Synthesized compounds have pronounced antiarrhythmic activity and low toxicity.

引用

页码：131 / 136

页数：6

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