Ag-Mediated Radical Cyclization of 2-Alkynylthio(seleno)anisoles: Direct Synthesis of 3-Phosphinoylbenzothio(seleno)phenes

被引：44

作者：

Cai, Tao ^{[1
]}

Liu, Jian ^{[1
]}

Zhang, Huimiao ^{[1
]}

Wang, Xiaolong ^{[1
]}

Feng, Jing ^{[1
]}

Shen, Runpu ^{[1
]}

Gao, Yuzhen ^{[2
]}

机构：

[1] Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China

[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 12期

关键词：

BENZOTHIOPHENE; DISCOVERY; ALKYNES;

D O I：

10.1021/acs.orglett.9b01510

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the direct synthesis of 3-phosphinoylbenzothio(seleno)phenes has been achieved through an Ag-mediated radical addition-cyclization of 2-alkynylthio(seleno)anisoles with secondary phosphine oxides in good yields under mild conditions. In this single reaction, benzenethiophene or benzeneselenophene skeleton, C(sp(2))-P and C(sp(2))-S bonds can be constructed with the cleavage of the C(sp(3))-S bond, highlighting the efficiency and step-economics of this protocol.

引用

页码：4605 / 4608

页数：4

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