Synthesis of adenophostin A

被引：28
作者：
Marwood, RD
Correa, V
Taylor, CW
Potter, BVL
机构：
[1] Univ Bath, Wolfson Lab Med Chem, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England
[2] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 02期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1016/S0957-4166(99)00491-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The natural product and potent agonist of the D-myo-inositol 1,4,5-trisphosphate receptor, adenophostin A, was synthesised from adenosine and D-glucose using efficient methodology. The synthetic material was equipotent with naturally occurring adenophostin A in evoking Ca(2+) release from the intracellular stores of permeabilised cells. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：397 / 403
页数：7
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